Trends in Corneal Transplantation and Characteristics of Donors in the Chongqing Eye Bank, China: A Retrospective Study, 1999-2018.
Trends in Corneal Transplantation and Characteristics of Donors in the Chongqing Eye Bank, China: A Retrospective Study, 1999-2018.
复制标题
DOI：
10.3389/fmed.2021.750898
复制
发表时间：
2021
影响因子：
3.9
通讯作者：
Li H
中科院分区：
文献类型：
--
作者：
Tan H;Lin M;Gou Q;Li A;Gu F;Liu Q;Zhang Q;Xu M;Kijlstra A;Yang P;Li H
目的：分析重庆市中国眼库角膜移植趋势及自愿捐献者特征。方法：我们回顾和分析了1999年1月1日至2018年12月31日的资料，包括5397例登记在册的自愿供者、1955例实际供者、3910例捐赠组织和2374例角膜移植。结果：5397名登记前捐献者包括13个民族，总体平均年龄为39.6岁(SD 21.5)，其中3010名为女性(55.8%)。大专及以上文化程度最高(2546人，47.2%)，汉族最多(5335人，98.85%)。在1,955名实际捐献者中，男女比例为3.3，平均年龄为57.1岁(SD 23.0岁)。从2018年人口规模来看，江北县捐献意愿最活跃，人均捐献意愿为60×10−6；榆中县捐献角膜最活跃，人均捐献意愿为45 1×0−6。在3910个捐献的角膜中，2540个(65.0%)用于临床。在未使用的角膜中，978例(71.4%)因角膜质量差而被拒收。其中2374例(93.5%)在重庆医科大学附属第一医院眼科完成，其余166例(6.5%)在其他中心完成。其中穿透性角膜移植1671例(70.39%)，前板层角膜移植700例(29.49%)，角膜内皮移植3例(0.13%)。每年的角膜移植数量增加了近10倍，从1999年的35例增加到2018年的327例。其中，穿透性角膜移植和前板层角膜移植分别从1999年的27例和8例增加到2018年的230例和94例。感染性角膜炎(37.0%)是角膜移植的主要适应症，其次是角膜瘢痕(19.8%)。在研究期间，角膜疤痕从第一位(1999-2003年的41.1%)下降到第二位(2014-2018年的20.5%)，而感染性角膜炎则领先，从1999-2003年的12.2%到2014-2018年的26.3%不等。结论：本研究报道了重庆市近20年来角膜捐献和移植的趋势，表明感染性角膜炎是角膜移植的主要适应症，穿透性角膜移植和前板层角膜移植呈上升趋势。分析进一步表明，潜在的预注册角膜捐赠者是一名汉族女性，具有较高的教育水平。
Aim: This study aimed to analyze corneal transplantation trends and voluntary donor characteristics at the Chongqing Eye Bank in China. Methods: We retrospectively reviewed and analyzed data from January 1, 1999, to December 31, 2018, covering 5,397 preregistered voluntary donors, 1,955 actual donors, 3,910 donated tissues, and 2,374 corneal transplantations. Results: The 5,397 preregistered donors included 13 ethnic groups, with an overall mean age of 39.6 years (SD 21.5) and 3,010 were women (55.8%). The most prevalent education level was college and above (2,546, 47.2%), and the most common ethnic group was Han (5,335, 98.85%). Of the 1,955 actual donors, the male-to-female ratio was 3.3, and the mean age was 57.1 (SD 23.0 years). Based on population size in 2018, Jiangbei county was the most active in donation willingness, with ~60 × 10−6 per capita, and the Yuzhong county was the most active in cornea donations, with ~451 × 0−6 per capita. Of the 3,910 donated corneas, 2,540 (65.0%) were clinically used. Of those not used, 978 (71.4%) were rejected for poor corneal quality. The 2,374 (93.5%) corneal transplantation procedures were done at the Department of Ophthalmology of the First Affiliated Hospital of Chongqing Medical University and the rest (n = 166, 6.5%) were performed in other centers. Of those 2,374 corneal transplantations, there were 1,671 penetrating keratoplasty (70.39%), 700 anterior lamellar keratoplasty (29.49%), and three corneal endothelial transplantations in our center (0.13%). The number of annual corneal transplantations increased by nearly 10 times, from 35 cases in 1999 to 327 cases in 2018. Among them, cases of penetrating keratoplasty and anterior lamellar keratoplasty increased from 27, and eight cases in 1999 to 230 and 94 cases in 2018, respectively. Infectious keratitis (37.0%) was the leading indication for keratoplasty, followed by corneal scar (19.8%). Over the study period, corneal scars dropped from the first (41.1% in 1999–2003) to the second indication (20.5% in 2014–2018), while infectious keratitis advanced to take the lead, ranging from 12.2% in 1999–2003 to 26.3% in 2014–2018. Conclusion: Our study reports corneal donation and transplantation trends in Chongqing over 20 years, showing that infectious keratitis is a leading indication for keratoplasty and that penetrating keratoplasty and anterior lamellar keratoplasty show upward trends. The analysis further suggests that a potential preregistered cornea donor is a female Han, with a higher education level.
登录
查看更多内容
影响因子：
2
作者：
Rezaei Kanavi M;Javadi MA;Motevasseli T;Chamani T;Rezaei Kanavi M;Kheiri B;Safi S
通讯作者：
Safi S
影响因子：
0.9
作者：
Frigo, A. C.;Fasolo, A.;Ponzin, D.
通讯作者：
Ponzin, D.
影响因子：
2.8
作者：
Tan, Johnson C. H.;Holland, Simon P.;Yeung, Sonia N.
通讯作者：
Yeung, Sonia N.
影响因子：
3.3
作者：
Pendela, Venkata Satish;Kudaravalli, Pujitha;Lesho, Emil
通讯作者：
Lesho, Emil
影响因子：
4.1
作者：
Keenan, Tiarnan D. L.;Carley, Fiona;Goldacre, Michael J.
通讯作者：
Goldacre, Michael J.