踝关节骨关节炎发病率为1%，人工踝关节置换术是治疗晚期踝关节骨关节炎的重要手段。我国人口超过13亿，临床需求巨大，但目前假体10年生存率只有70%，医患面临风险较高。其根本原因在于：唯一直立行走的特性导致踝关节生物力学复杂、没有动物模型可复制、假体设计必需的踝关节功能解剖学与运动学参数不明确。本项目拟基于青年基金项目(30801161)的结果，将解剖学数据、CT扫描立体模型与三维有限元模型结合，研究踝关节的骨性与韧带解剖学数据、距骨曲率半径、距骨瞬时旋转中心轨迹、关节接触面积与应力变化等功能解剖学参数；双平面透视匹配技术与“四维六自由度足踝数控模拟系统“结合，实现踝关节正常步态周期的匹配重建和运动学参数测量。进而分析步态周期中踝关节骨骼-关节-韧带-肌肉系统之间的协调控制机理、关节接触面积-力学变化-力学中心轨迹之间的动态偶联机制与规律、为适用于国人的人工踝关节假体设计、优化提供理论支持。

The incidence of ankle osteoarthritis is 1%. Total ankle replacement is an important operative procedure for end-stage ankle osteoarthritis. Our country has a population of more than 1.3 billion, the clinical demand is huge. The 10-year survival rate of total ankle prosthesis is only 70%.The risks of surgeon and patient are both high. The basic reason is the anatomical and kinematics characteristics of normal ankle is not clear. But these data are very important for prosthesis design and update. The only upright-walking features lead to complex biomechanics of the ankle and there is not any animal model can simulate the normal gait cycle of human. This project want to integrate the anatomical data and 3D reconstructed model with 3D finite element model based on the result of project 30801161. With the method, we can study the anatomical characteristics of normal ankle, radius of curvature of talus, instantaneous center of rotation of talus, joint contact area and stress changes of ankle. Biplanar fluoroscopy matching technology and 4D 6-Freedom ankle simulate system can measure the kinematics characteristics of normal ankle. So we can analysis the coordination control mechanism of bone-ligament-muscle complexity. So we can study the law of interaction between stress changes and mechanical center trajectory of ankle joint. We will gain theories necessarily for ankle prosthesis design and improvement.