玉米醇溶蛋白（Zein）为营养物加载体系构建提供了崭新平台，但在应用中出现新的难题，如乙醇是禁止使用在非酒精类食品中，且易燃；胶粒聚集难以精细控制，粒径大且分布宽等。为此，项目设计以丙二醇替代乙醇、超声透析驱动窄分布及小粒径聚集、原位光谱技术实时监控组装与聚集过程，研究基于分子组装技术和原位实时光谱技术的超声透析调控相分离驱动α-Zein微纳尺度聚集机制，构建营养物加载体系新型的精细化控制技术。以构建微观结构和宏观形貌与多重多相声学响应关系、解析超声透析调控相分离驱动α-zein组装与聚集机制等为关键科学问题，采用计算、模拟、设计和验证紧密结合，计算和模拟α-Zein自组装过程，设计超声透析、丙二醇相分离、α-Zein新型加载技术体系，验证薄荷油、维生素、姜黄素等营养物加载特性。项目为拓展食源性载体材料构建营养物加载体系的多重声学透析响应与多相复杂体系中声学、透析驱动机制等研究提供基础。

Zein has provided a new platform for nutrition loading system, but further study there are new problems, such as alcohol is banned for use in nonalcoholic food and flammable, micelle aggregation serious and particles in lager size and wide distribution. Therefore, the present project design with propylene glycol instead of alcohol, ultrasonic dialysis drive narrow distribution and small particle size and in situ and real-time spectroscopic technology for monitoring of self-assembly and aggregation process. Based on technologies of in situ and real-time spectroscopic technology and molecular assembly to clarify and obtain mechanism in ultrasonic dialysis drive α-zein micro/nano scale gathering and the construction of new green nutrient loading system. The key scientific issues are the constructing of response relationship between microstructure and macromorphology and the mechanism of ultrasound and dialysis regulating phase separation drives the assembly and loading of alpha-Zein. The project will be carried with combination of calculation, simulation, design and verification. The method of calculation and simulation used for study of self-assembly process of α-zein and ultrasonic dialysis drive, design method for analysis of ultrasonic dialysis, α-zein and the propylene glycol, verification method for peppermint oil, vitamins and other food nutrient loading in the new system. The project provides the basis for the development of the multiple acoustic responses of the nutrient loading system and the ultrasonic dialysis driven mechanism in the multi-phase complex system for further related work.