显微术后吻合区灌注状态是影响游离皮瓣成活的核心因素，开发术后对血管灌注状态长期实时监测的技术具有重大的临床应用意义。术后灌注障碍在动/静脉的近心端和远心端分别表现为迥异的血管形变和搏动模式，目前尚缺乏对于这类高频率微小形变（>3Hz，<5%）生物信号的实时传感技术。我们前期成功研发出基于蛋清水凝胶自发固-液相转变的液态导体能够无延迟识别高频微小形变力学信号并转化为无损电学信息。但是目前吻合区不同灌注状态下的血管形变和脉搏的力学信息以及对应的电信号之间的关联模型仍是空白。故本项目结合前期研究成果，借助新型蛋白质液态导体构建高频响应血管传感器，通过仿生血管吻合和动物实验相互印证，系统分析不同灌注状态血管生理力学与电学信号转换的关联机制，全面建立吻合区灌注的数学动态模型。本课题的研究为便携一体式新型血管传感器提供全新的材料和设计模型，同时也为建立血管吻合皮瓣移植的干预治疗提供有力的理论依据。

The vascular perfusion status after microvascular anastomosis is considered as the critical factor affecting the survival of free skin flap. The development of long-term along with real-time monitoring of postoperative vascular perfusion has great clinical significance. The perfusion disorders show distinct patterns in the aspect of vascular deformation and pulsation at the proximal and distal ends of the arteries and veins, respectively. At present, there is still challenging for real-time monitoring such biological signals with high-frequency and micro-deformations (> 3Hz, < 5%). We have successfully developed a novel liquid conductor based on the spontaneous solid-liquid phase transition of egg white hydrogel, which can recognize this kind of micro-mechanical signals with high-frequency in real time and convert the biological information into nondestructive electrical data. However, the current correlation model between the mechanical information of vascular deformation as well as pulse and the corresponding electrical data under different perfusion conditions in the anastomosis area is still blank. Therefore, combining our previous results, this investigation will construct a vascular sensor based on egg white liquid conductor featured with high-frequency response, systematically analyze the correlation mechanism between vascular physiology and electrical signal conversion in different perfusion states through cross validation by biomimetic vascular anastomosis model and animal experiments, and comprehensively establish mathematical dynamic model of perfusion in the anastomosis area. The results will provide an innovative material and design for the portable integrated vascular sensor, and also offer strong theoretical conclusions for the establishment of interventional standard of free flap transplantation with microvascular anastomosis.