颅内动脉狭窄是中国人群缺血性脑卒中的重要危险因素,也是脑卒中遗传学研究理想的中间表型。脂蛋白相关磷脂酶A2（Lp-PLA2）是近年来广受关注的炎症因子。我们前期在未发生过脑卒中的高血压患者中，发现Lp-PLA2的血浆水平与颅内动脉狭窄相关。因此我们假设，Lp-PLA2相关基因可能与中国人群颅内动脉狭窄的发生相关。为验证以上假说，拟开展以下工作：（1）对955例未发生过脑卒中的高血压患者进行为期5年的随访，研究Lp-PLA2相关位点与高血压患者颅内动脉狭窄发生和发展的关系;（2）研究血压水平及血压的波动对于Lp-PLA2相关基因与高血压患者颅内动脉狭窄相关性的影响;（3）研究发现阳性位点对于外周血单核细胞-诱导巨噬细胞Lp-PLA2浓度和活性的影响。从而阐明Lp-PLA2与我国高血压患者颅内动脉狭窄发生发展的关系，为高血压患者脑卒中个体化预防和治疗提供新的证据。

Intracranial arterial stenosis is one of the most important risk factors of ischemic stroke, and is an ideal intermediate phenotype of genetic study on stroke. Lipoprotein-associated phospholipase A2 （Lp-PLA2）is a novelty inflammatory factor. In our previous study, we found that Lp-PLA2 mass was associated with intracranial arterial stenosis in stroke-free hypertensive patients in Chinese population. Therefore, we hypothesize that Lp-PLA2 related genes may associate with intracranial arterial stenosis. To test the hypothesis, we aim to (1) carry out a five years prospective study in 955 asymptomatic hypertension patients, in order to detect the relationship between Lp-PLA2 related genes and intracranial arterial stenosis in stroke free hypertensive patients, (2) explore the effect of blood pressure level and blood pressure variance on association of Lp-PLA2 related genes with intracranial arterial stenosis, (3) test the effect of the positive loci on the Lp-PLA2 expression and enzyme activity in peripheral blood monocyte derived macrophage. This study will illustrate the relationship of Lp-PLA2 and the pathogenesis of intracranial arterial stenosis in stroke-free hypertensive patients in Chinese population, and provide the new evidence for stroke prevention and treatment.