基于脑-机-肌信息环路的卒中助行康复机器人基础理论与关键技术

脑卒中是严重危害人类生命健康的常见高发病。探索新型康复治疗机理与方法已成为世界范围，尤其是我国关注的焦点。而大脑可塑性的康复机制研究亦成为当前神经科学研究前沿热点。课题拟针对现有康复训练无法有效实现主观意愿诱导脑-肌协同运动的难题，深入研究脑可塑性在卒中康复中的神经信息融合机制并结合功能性电刺激、机械外骨骼技术新手段，开发机-电助行康复新方法；依托脑-机接口前沿技术建立面向助行康复神经机器人的脑-机-肌协同交互信息环路模型；开展基于脑功能网络、脑-肌电相干性的可塑性变化检测与分析研究，探索提高人机信息交互紧密性与中枢神经可塑性诱导功效的关键措施，增强患者脑-机-肌协同助行的功能康复效果，建立新型康复评价的客观标准。本研究将为推进中枢神经可塑性康复机制深入研究提供新的科学依据和实用模型，并为研制具有智能控制、安全监护等多功能的新型脑-机-肌协同助行康复机器人系统奠定关键技术基础。

Stroke is a common disease with high incidence severely threatening the health of human beings. The technology of stroke rehabilitation has become a new research focus in worldwide, especially China. Meanwhile, the mechanism of brain plasticity rehabilitation has also developed into a researching hotspot of neuroscience. Aiming at the problem that the existing stroke rehabilitation methods cannot implement subjectively induced brain-machine-muscle coordinating action effectively, this project provides a profound research about the neural information fusion mechanism of brain plasticity in stroke rehabilitation and develops new rehabilitation technology for machine-electricity assisted-walking combining functional electrical stimulation and mechanical exoskeleton. Close-loop information model of brain-machine-muscle synergistic interaction towards neural rehabilitation robot will be built based on advanced technologies of brain-computer interface. By detecting and analyzing the plasticity changes based on the brain function connection and the cortico-muscular coherence., this project will explore the key solutions to which can enhance tightness of close-loop human-machine information interaction and effect of neural plasticity inducement, and improve the rehabilitation effect of patients’ brain-machine-muscle coordinative function. In addition, objective rehabilitation evaluation standards will be established. This project will provide scientific basis and practical model for in-depth investigation of central neural plasticity rehabilitation mechanism. Furthermore, it will also provide key technologies for developing the brain-machine-muscle synergistic interaction for assisted-walking rehabilitation robot with multi-function such as intelligent control and security monitoring.