压电喷雾-电晕电离接口在质谱分析热不稳定以及痕量环境污染物的应用

质谱是现今最灵敏的检测器之一，常用的进样接口有电喷雾电离、大气压化学电离和大气压光电离等接口，电喷雾电离仅适用于强极性物质，大气压光电离则用于含共轭结构的化合物，大气压化学电离适合于中等及弱极性物质。大气压化学电离中一般先采用气动雾化将液体样品转化为气溶胶，然后再电晕放电使分析物电离。气动雾化效率低，降低了质谱灵敏度，而大量的去溶的高温气体会导致热不稳定物质的分解并造成浪费。本申请研制基于压电效应的微液滴雾化器，结合电晕电离作为质谱的进样接口，可提高进样效率，改善灵敏度，降低惰性气体的使用量和电离接口的温度。进一步研究该接口用于热不稳定物质直接分析的方法和痕量环境污染物的方法，实现快速、高灵敏的分析。

As one of the most sensitive detectors nowadays, mass spectrometry typically adopts electrospray ionization, atmospheric pressure chemical ionization or atmospheric pressure photoionization for sample introduction, which are most favorable for strong polar compounds, conjugated compounds, and moderate and weak polar compounds, respectively. By using atmospheric pressure chemical ionization source, liquid sample is normally nebulized pneumatically into aerosols prior to ionization by corona discharge. Pneumatic nebulization suffers from low nebulising efficiency, and hence leads to low sensitivity. More worse, usage of bulk gas stream of high temperature for desolvation would break down thermolabile compounds and increase the expense. This application tries to improve sampling efficiency and enhance sensitivity in mass spectrometry by fabricating a new ionization source comprising of piezoelectric microdroplet generator and corona ionization. Volume of gas stream and source temperature are anticipated to be decreased dramatically. Thereafter new methodologies for rapid and highly sensitive analysis of thermolabile compounds and trace environmental pollutants would be developed based on the novel source.