茶叶中的天然功能性成分儿茶素与心脑血管健康关系紧密，研究其抗血栓作用机理具有积极意义。本项目以不同构型的茶叶儿茶素为研究对象，利用人体血液"炎症-血栓网络"模型，采用人体分离纯化血小板、白细胞以及全血，研究儿茶素抗血栓和调节炎症的作用机理。主要内容有：（1）儿茶素对不同途径引起的血小板活性变化的影响;（2）儿茶素对血小板和白细胞分别介导的环氧化酶、脂氧化酶作用的影响;（3）儿茶素在炎症-血栓网络中的作用。本项目拟在分子结构水平上讨论儿茶素的抗血栓作用，全面探讨儿茶素与血小板活化、炎症因子的作用关系。研究结果可以为利用儿茶素作为天然抗血栓药物提供理论依据，为酶学水平上分析儿茶素对炎症相关血栓网络的作用提供参考，对深入研究茶叶天然功能性成分的药用机理具有重要意义。

The proposed research is on the mechanism of catechins' antithrombotic effect using human inflammation-thrombosis cells system. Catechins are important functional ingredients in tea products which have a beneficial effect in different human diseases, like thrombosis and other cardiovascular diseases. In this research, catechins with different structures/configurations will be used to study their effect on human platelet aggregation induced in diverse pathway. .A combination of purified platelets, leukocytes and whole blood will be used as different cell models to study the interaction between inflammation and coagulation within the system of human blood. The research will include: (1) Effect of catechins on platelet activity in different pathways; (2) Effect of catechins on platelet induced cyclooxygenase and leukocyte mediated lipoxygenase; (3) Effect of catechins on the interplay of inflammation and thrombosis system. .We will discuss the antithrombotic effect of catechins with its macromolecular structure and configuration, and have a comprehensive study of its relationship with platelet activation and relative inflammatory factors. The results of this research will provide a theoretical basis for the use of catechins as natural antithrombotic drugs. It benefits to analysis the effect of catechins on inflammation related blood thrombosis on the level of different enzymes, providing a great significance to further pharmacological study on natural tea functional ingredients