课题基金基金详情
面向心血管病标志物浓度植入式监测的ssDNA-GFET纳米传感器的研究
结题报告
批准号:
52005137
项目类别:
青年科学基金项目
资助金额:
24.0 万元
负责人:
郝壮
依托单位:
学科分类:
微纳机械系统
结题年份:
2023
批准年份:
2020
项目状态:
已结题
项目参与者:
郝壮
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中文摘要
本项目对单链脱氧核糖核酸-石墨烯场效应管(ssDNA-GFET)纳米生物传感器在心血管疾病标志物浓度植入式监测应用中面临的科学问题进行实验研究与理论分析,主要包括:(1)通过调控ssDNA探针修饰密度和捕获标志物分子电荷与石墨烯表面距离从而提升ssDNA-GFET检测性能参数的方法研究;(2)实验分析聚氧乙烯失水山梨醇脂肪酸酯、聚乙二醇等化学分子修饰,氧化物纳米层蒸镀等方法在保护石墨烯免受血液中非目标物干扰,提升ssDNA-GFET检测稳定性的有效性;(3)利用六方氮化硼作为栅介质研制柔性埋栅型ssDNA-GFET,并研究机械形变应变量变化对GFET电学性能指标的影响及消除影响的方法。此外,课题的成功研究将使ssDNA-GFET对血液中新冠肺炎标志物白细胞介素-6的检测成为可能,为类似疫情发生早期的快速筛检提供一个新思路与新方法。
英文摘要
This study focuses on addressing problems that hamper the application of single-stranded deoxyribonucleic acid probe based graphene field effect transistor (ssDNA-GFET) bio-nanosensor for implantable monitoring of cardiovascular disease biomarkers by systematic experiments and theoretical analysis. First, investigating the method to enhance sensing parameters by regulating and controlling the ssDNA grafting density and the distance between charged biomarker molecules and graphene surface. Second, examining the validity of graphene surface coated Tween layer, PEG layer and oxide deposition layer on preventing graphene from nonspecific interferences in blood and enhancing the sensing stability of ssDNA-GFET by experiments. Third, fabricating flexible ssDNA-GFET with a buried grate configuration employing h-BN as the gate dielectric. Studying the effect of the change in mechanical deformation strain on GFET electrical properties and figuring out the way to effectively eliminate such effects. Additionally, results of this study would realize detection of corona virus disease 2019 biomarker interleukin-6 in blood using ssDNA-GFET, offering a new way for diagnostics of such kinds of epidemic diseases at early stage.
期刊论文列表
专著列表
科研奖励列表
会议论文列表
专利列表
DOI:10.1002/admt.202101131
发表时间:2022-02-09
期刊:ADVANCED MATERIALS TECHNOLOGIES
影响因子:6.8
作者:Huang, Cong;Hao, Zhuang;Pan, Yunlu
通讯作者:Pan, Yunlu
DOI:10.1002/adfm.202309447
发表时间:2023-11-27
期刊:ADVANCED FUNCTIONAL MATERIALS
影响因子:19
作者:Huang,Cong;Li,Dongliang;Pan,Yunlu
通讯作者:Pan,Yunlu
DOI:10.1016/j.mtchem.2021.100635
发表时间:2021-11-25
期刊:MATERIALS TODAY CHEMISTRY
影响因子:7.3
作者:Huang, C.;Hao, Z.;Pan, Y.
通讯作者:Pan, Y.
A closed-loop catalytic nanoreactor system on a transistor.
晶体管上的闭环催化纳米反应器系统。
DOI:10.1126/sciadv.adj0839
发表时间:2023-09-22
期刊:SCIENCE ADVANCES
影响因子:13.6
作者:Wang, Xuejun;Xia, Binbin;Hao, Zhuang;Kang, Hua;Liu, Wentao;Chen, Yiheng;Jiang, Qunfeng;Liu, Jingyuan;Gou, Jian;Dong, Baijun;Wee, Andrew Thye Shen;Liu, Yunqi;Wei, Dacheng
通讯作者:Wei, Dacheng
DOI:10.1016/j.xcrp.2022.100855
发表时间:2022-04
期刊:Cell Reports Physical Science
影响因子:8.9
作者:Ziran Wang;Z. Hao;Chun Yang;Hao Wang;Cong Huang;Xuezeng Zhao;Yunlu Pan
通讯作者:Ziran Wang;Z. Hao;Chun Yang;Hao Wang;Cong Huang;Xuezeng Zhao;Yunlu Pan
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海外基金