目前2型糖尿病的病因及发病机理尚未完全阐明，大量研究表明遗传因素可能在其发病机制中起着重要作用。本研究采用来源于队列人群的前瞻性巢式病例对照研究和人群家系研究结合的研究设计，选取在糖代谢过程中与空腹血糖和胰岛素分泌相关的基因G6PC2和GCKR，探讨中国汉族人群G6PC2和GCKR基因与2型糖尿病的遗传关联强度，分析基因与环境因素间的交互作用，筛选中国汉族人群2型糖尿病的遗传标志物，为进一步探索2型糖尿病的发病机制提供科学依据。同时分析G6PC2和GCKR基因与空腹胰岛素、甘油三酯的定量关联强度，阐明G6PC2和GCKR基因影响血糖和血脂代谢的作用机制。

The etiology and pathogenesis of type 2 diabetes is not fully elucidated upto now, a large number of studies have shown that genetic factors may play an important role in its pathogenesis. In this study we plan to select genes related glucose metabolism to explore G6PC2 and GCKR gene genetic association with type 2 diabetes by adopting prospective nested case-control study and family design derived from the cohort study and analyze gene-environment interaction in Han Chinese, so as to provide ascientific basis for a further exploration of the pathogenesis of type 2 diabetes disease.Meanwhile, we analyze quantifying association between G6PC2, GCKR gene and triglyceride, fasting insulin to clarify the mechanism of G6PC2 and GCKR gene affecting glucose and lipid metabolism.