胚胎植入和蜕膜发育是决定妊娠成功的两个关键环节，并受到子宫细胞内多种分子的精确调控。先前研究证实Wnt5a、Wnt4蛋白参与调节植入和蜕膜化，而其卷曲蛋白受体Frizzled是否介导两类配体并通过非经典Wnt信号通路发挥功能尚不清楚。申请人在前期研究中发现子宫条件性敲除Frizzled2影响蜕膜反应和胚胎发育。本项目拟进一步研究子宫Frizzled2分子是否介导Wnt5a和Wnt4配体，以及Wnt-Frizzled2信号影响胚胎植入和蜕膜化的分子调控机制，以期揭示非经典Wnt-Frizzled2通路对妊娠建立与维持的关键作用，为临床相关妊娠疾病提供理论依据。

Embryo implantation and decidualization are two critical events occurred in the uterus for the successful pregnancy, which are precisely under the control of many uterine molecules. Previous studies demonstrated that Wnt5a and Wnt4 protein had participated in regulating these two processes, while it remains elusive whether uterine Frizzled receptor mediates these two ligands in regulating implantation and decidualization through non-canonical Wnt signaling pathway. In the present project, we showed decidual reaction and embryonic development are disrupted by conditional knockout of uterine Frizzled2. We intend to further investigate whether uterine Frizzled2 receptor mediates Wnt5a and Wnt4 ligands, and the specific molecular mechanism of Wnt-Frizzled2 signaling pathway in regulating implantation and decidualization, attempting to comprehensively reveal the function of uterine non-canonical Wnt-Frizzled2 signaling during pregnancy establishment and maintenance, and provide theoretical basis for related pregnancy diseases.