绿茶在健康促进方面的作用日益获得认可促进了其在世界范围内的使用。绿茶与药物同时在人体内使用可能带来潜在的药物相互作用。中国民间自古有“茶能解药”之说，而《太平惠民合剂局方》之“川芎茶调散”明确说明该散“食后用茶清调下”。饮茶对药物PK-PD影响及其作用机制如何是需要解决的科学问题。兰索拉唑是一种临床应用广泛的质子泵抑制剂，直接作用于H+-K+-ATP酶抑制胃酸分泌，主要经CYP3A4及CYP2C19代谢。已有动物研究表明，饮用绿茶对兰索拉唑及其代谢产物的影响可能与茶多酚诱导CYP2C19有关。本研究拟通过一项重复饮用绿茶后单次服用兰索拉唑的随机、对照、交叉设计的PK-PD临床研究，利用Pharsight NLME软件建立PK-PD模型，研究饮用绿茶对兰索拉唑及其代谢产物在健康人体内的药代动力学及药效学影响，并试图探索CYP2C19基因型在绿茶对兰索拉唑药代及药效动力学影响中的作用机制。

Effects of green tea on health promotion are increasingly reported，and the likelihood of concomitant use of green tea and medicines is thought to be increasing. This may bring potential dietary food versus drug interactions. There is a Chinese saying in folk that " Tea can reduce the efficacy of drugs," while "Chuan-Xiong-Cha-Tiao San" in "Formularies of the Bureau of People’ s Welfare Pharmacies" clearly say "Use tea to administrate the powder after meals". So it is important scientific issues need to be addressed that how green tea affect the metabolism of drugs effect and its mechanism. Lansoprazole is a widely used proton pump inhibitor, mainly degraded by CYP3A4 and CYP2C19. Animal studies have indicated that the impact of green tea to Lansoprazole and its metabolites may be attributed to CYP2C19 phenotypes. This study is a randomized, controlled and cross-over designed clinical study. 20 healthy volunteers received a single oral dose of 40 mg Lansoprazole after repeated consumption of green tea, aiming at evaluating effects of green tea on pharmacokinetics and pharmacodynamics of Lansoprazole. At the same time, we will establish a PK-PD modeling and try to find the mechanism of the effect based on the CYP2C19 phenotypes.