结直肠癌是临床上最常见的消化道恶性肿瘤之一，结直肠癌术后复发是影响其疗效及预后的主要问题，目前尚缺乏有效的治疗手段。前期临床与基础研究表明，血管的生成及免疫逃逸是结直肠癌术后复发的重要机制，消瘤汤具有拮抗血管生成、提高免疫功能的作用。在此基础上，本项目拟采用人大肠癌裸小鼠移植瘤动物模型，运用基因芯片、fish、RT-PCR等技术研究消瘤汤对裸鼠大肠移植癌血管生成关键分子及TLR信号的调控作用。通过本项目的研究，深入探讨结直肠癌术后复发的机制中，血管生成及TLR信号相关调控基因和相关功能基因蛋白产物与其他蛋白或核酸的联系网络，以及它们在转录、翻译调控中的作用及消瘤汤的干预作用，为确定结直肠癌术后复发的预测指标和新的治疗靶点提供理论和实践基础，为今后在临床上采用中药制剂防治结直肠癌术后复发提供理论研究。

Colorectal cancer is one of the most common clinical malignant tumor of the digestive tract,and postoperative recurrence in colorectal cancer is the main problem of affect its curative effect and prognosis that is lack of effective treatments now.the early clinical and basic research of the Research Group shows that the formation of blood vessels and immune to escape is an important mechanism of colorectal cancer recurrence,and xiaoliu decoction has the function of anti-angiogenesis and improve the immune. On this basis, this project to use the animal model of immunodeficiency mice transplanting people's colorectal cancer , Using genetic chips, fish, RT-PCR technology to research the effects of xiaoliu decoction on key molecules of angiogenesis and TLR signal transduction in colorectal cancer transplanted on immunodeficiency mice.Through the research of this project , deeply discuss the mechanism of colorectal cancer recurrence and of postoperative, network of angiogenesis and TLR signal transduction related control gene and products of functions gene protein contact with other protein or nucleicacid,and their role in the transcription and translation regulation,and the intervention role of xiaoliu decoction.Provide the theory and the practice foundation with the prediction indexes and new therapeutic targets of colorectal cancer postoperative recurrence.Provide the theory research with preventive treatment colorectal cancer recurrence used of Chinese medicine preparation in clinic in the future .