安全关键系统是指功能一旦失效将引起生命、财产的重大损失以及环境遭到严重破坏的系统，具有性能双重性、失效复杂性、要求严格性、损失重大性的特点，系统Signature在复杂系统设计及性能分析上具有特有的优势，可以有效解决安全关键系统分析中的一些瓶颈问题。.本项目针对安全关键系统的安全、危险二元故障模式，从可靠性、安全性两个角度提出安全关键系统的Signature分析方法。建立系统的Signature指标，分析系统结构设计优良性；从静态和动态两个层面，建立系统可靠性与安全性分析方法，分析其大小关系及动态变化规律；建立基于Signature序的系统剩余寿命随机比较方法；建立可靠性、安全性及经济性综合目标的优化模型和方法，实现系统最优设计选择和性能配置。.预期成果不仅可扩展可靠性、安全性分析方法，丰富Signature理论，而且对改善安全关键系统设计、提升安全保障能力具有重要的科学意义和实用价值。

Safety-critical systems are those systems whose failures could result in loss of life and serious damage to the property or the environment. It is characterized by double performance of reliability and safety, complex failure modes, strict demands of performance, and great losses of failure. For complex systems, Signature has its unique advantages in the design and performance analysis. It can solve some bottleneck problems effectively in the analysis of the safety-critical systems..According to the characteristics of the safe failure and dangerous failure of the safety-critical systems, this project builds Signature analysis method for the safety-critical systems from reliability and safety aspects. (1) Propose the analysis method of system structure design based on Signature theory. (2) Analyze the calculation method of the reliability and safety from static and dynamic aspects. Reveal the influence rule and dynamic variation of reliability and safety. (3) Study the stochastic comparisons of the residual lifetime based on the Signature order. (4) Establish the reliability, safety and economy optimization model and propose the algorithm to achieve optimal design and performance configuration. .The research results of this project do not only extend the methods of analysis for reliability and safety, but also enrich the Signature theory. It is also of great scientific meaning and practical value for improving the design and safety supportability of safety-critical systems.