磁性纳米粒子在磁性靶向定位与药物控制释放等生物医药领域有着广阔的应用前景，但是其磁性稳定性不好，生物相容性较差及制备方法过程复杂等问题限制了其应用。在我们的前期工作中采用water-assisted CVD（混和水蒸气气相沉积法）的方法原位合成了功能化磁性纳米管。磁性纳米管的合成过程简单且纳米管表面引入了一定量的功能化基团，这在一定程度上可以解决上述的磁性纳米粒子在应用中的问题。基于water-assisted CVD法原位包裹磁性金属制得纳米管磁性较稳定、过程易于开展且可控、可实现原位功能化等优点，本项目拟采用water-assisted CVD原位包裹磁性金属Ni、Co、Fe制备磁性纳米管，围绕提高纳米管磁性稳定性，改进分散性、生物相容性和控制磁性纳米金属的尺寸及包裹率等核心问题展开系统研究。拟采用“磁性碳管制备→构效关系研究→反馈制备过程”的技术路线，指导合成稳定性强，生物相容性好及

Magnetic nano-particles have a promising market in magnetic targeted positioning and drug controlled release areas. Suffering from the poor stability, bad biological compatibility and complex synthesis process, the magnetic nano-particles haven’t been widely application in medicine and biology fields. In our previous works, the functional carbon nanotubes (CNTs) encapsulated magnetic metal nano-particles are prepared in situ by the water-assisted CVD. The synthesized CNTs are filled with magnetic metal nano-particles and amounts of functional groups are introduced on the MWCNT surface due to the introduction of water vapor in CVD, by which, the stability of magnetic metal, biological compatibility and drug transport properties of the synthesized magnetic carbon nanotubes are significantly improved. In this work, the magnetic metal Ni, Co and Fe are designed to apply as catalyst active metal for CNTs synthesis and the reaction condition will be adjusted to improve the fill rate of magnetic metal nano-particles during CVD. The investigating route follows the strategy: from material preparation to structure-activity relationship researches, and then guide the synthesis of magnetic CNTs which have favourable stability, biological compatibility and drug transport properties. This work can provide powerful evidences and theoretical basis in the applications of magnetic CNTs to bio-pharmaceutical fields.