染色体乘客复合体(CPC)是由 Survivin、 Aurora-B、 INCENP和Borealin组成，在细胞分裂过程中起到重要作用。申请者在前期工作中发现Survivin和Aurora-B在口腔鳞状上皮细胞癌（OSCC）中的表达密切相关，且两者的高表达与OSCC恶性度相关。 Borealin是CPC的新成员，在OSCC中的表达及与其他CPC蛋白的关系尚不明确。 预实验结果显示抑制Borealin在OSCC细胞中的表达，Survivin和Aurora-B的表达也随之降低，提示在OSCC中CPC蛋白之间是密切联系的。据此我们推测Borealin和其他CPC蛋白的相互作用可能影响蛋白质的相互稳定性及表达水平，从而促进OSCC的发生发展。本研究有望阐明CPC蛋白的相互作用对OSCC发生发展影响机制，为OSCC发生发展提供实验线索，在OSCC的预后、诊断及治疗等方面也具有重要意义。

The chromosomal passenger complex (CPC) consists of Survivin, Aurora-B, INCENP and Borealin and plays an important role in cell division. On the basis of previous studies, the applicant found that Survivin expression was correlated with Aurora-B expression, and high expresson of Survivin and Aurora-B was associated with a poor prognosis in OSCC.Borealin is a new member of the CPC, its expression in OSCC and its correlation with other CPC members is not clear. The preliminary experiment studies revealed that Borealin siRNA reduced Survivin and Aurora-B expression in OSCC cells. Suggesting that CPC proteins are closely linked in OSCC. Based on the aboved information, we hypothesize that interaction between Borealin and other CPC proteins may regulate their protein stability each other and level of expression,and promote the occurrence and development of OSCC. The research is expected to clarify the mechanisms of interaction of chromosomal passenger complex proteins in the occurrence and development of OSCC. It is providing clues for the occurrence and development of OSCC and is important in the prognosis, diagnosis and treatment in OSCC.