免疫佐剂是疫苗的重要组成部分。小分子激动剂,如瑞喹莫特（R848），作为非常优秀的佐剂候选者具有很强的抗病毒与抗肿瘤性能，然而其安全性存在隐患。大量研究中发现，佐剂的纳米颗粒形式，相较于它们的游离态有明显的优势。然而纳米佐剂的性质对免疫反应的影响，仍然需要大量研究。我们将制备纳米佐剂，使环境响应性作为其唯一的变量，探讨TLR7/8激动剂R848在从纳米材料中的环境响应性释放能力对疫苗免疫原性的影响。

Adjuvant is an important part of vaccines. The use of small molecule adjuvants, such as resiquimod (R848) has been hindered by their serious safety issues, despite the fact that they have shown excellent anti-cancer and anti-viral efficacy. From many studies, it is known that presentation of adjuvants in particulate form has clear advantages. However, there are many design parameters to be optimized for generating effective immune responses using nanotechnology. We plan to fabricate nanoparticulate adjuvants with responsiveness to the subcellular environment as the sole variable and study the effect of responsive release of TLR agonist from the nanoparticle on vaccine immunogenicity.