新型近红外双并氟硼二吡咯染料分子的合成与性能研究

近红外染料在生物医学和材料科学等领域有重要应用，发展具有良好光谱选择性和稳定性的近红外染料是目前备受关注的前沿研究领域之一。本课题旨在设计合成一系列2,3,2',3'-和1,7,8,1',7',8'-位直接并联的新型近红外双并BODIPY染料；发展构建这些近红外染料的新型高效合成方法；研究目标分子的光谱、光化学稳定性、电化学性能及其在细胞成像中的应用；分析比较并联位点、并联方式及电子效应对于染料性能的影响;以期开发出一类具有良好近红外光谱选择性及稳定性的新型近红外染料，发展几种具有良好溶解性及靶向性的新型近红外荧光探针。该项目为进一步有效设计新型近红外染料，尤其是双并BODIPY染料提供参考。

Near-infrared (NIR) dyes have found important applications in the fields of biomedical and material science.The development of NIR dyes with good spectral selectivity and stabilities is a frontier. In this project, we will design and synthesize a series of novel NIR 2,3,2',3'- and 1,7,8,1',7',8'-directly fused bisBODIPY dyes, develop a novel efficient synthetic method for these NIR dyes,study their spectral properties, photostabilities, electrochemical properties and potential applications in cell image, analyze the influence from the fused position, fused manner and the electronic properties on property of these novel NIR dyes. This project will lead to the generation of a new type of NIR dyes, featured with good NIR spectral selectivity and stabilities, and several NIR fluorescent probes with good water-solubility and/or targeting properties. This project will provide a good reference for the further development of novel NIR dyes, especially for those fused bisBODIPY dyes.