神经病理性疼痛是困扰人类健康的严重问题，目前尚缺乏有效的临床治疗措施。探讨神经病理性疼痛的作用机制具有重要意义。 TRESK是近年来发现的一个双孔钾离子通道，在背根神经节大量表达，主要功能为编码背景钾电流。我们的基础研究已证明：背根神经节的TRESK在神经病理性疼痛的发生、发展中起着重要作用。 Ras/MAPK信号通路是将胞外刺激信号转换至胞核内，产生转录和翻译后效应的信息传递通路。我们的前期工作已证明了MAPK信号通路在疼痛敏化调控的病理生理变化中的重要作用，而且相关文献也提示:Ras与TRESK调节的Ca2+信号密切相关。 本研究以RNA干扰和RNA过表达的慢病毒载体为工具，通过动物行为学、细胞生物学和分子生物学的实验方法，探讨背根神经节的TRESK通过Ras/MAPK信号通路参与神经病理性疼痛的作用机制,为神经病理性疼痛的治疗提供理论基础及新的治疗靶点。

Neuropathic pain is a serious problem affecting human health, but there is a lack of effective treatment at present. Researching into the mechanism of neuropathic pain is of great significance. TRESK, One of the two pore potassium ion channels, which was found in recent years, is expressed abundantly in dorsal root ganglia, and represents the most important background potassium channel.At present, our basic researches have demonstrated that the TRESK in dorsal root gaanglia plays an important role in the process of neuropathic pain. Ras/MAPK signal transduction pathway is the information transmission pathway which generated the effect of intracellular transcription and translation from the extracellular signals. It has been reported in our previous work that MAPK plays an important role in the regulation of pain sensitization of the pathophysiologic changes. Also,the related literature also suggests that Ras is closely related to the Ca2+ signal adjusted by TRESK. Using lentiviral vector with RNA interference and RNA over expression,we discussed TRESK involved in the mechanism of neuropathic pain through Ras/MAPK signal transduction pathwaythe by means of the experimental technique of animal ethology, cell biology and molecular biology. Hopefully, it can provide a theoretical basis and new therapeutic target for neuropathic pain.