发展新型高效的气体传感器，实现对三甲胺的高灵敏检测，对慢性肾病的早期呼吸诊断具有重要意义。很多半导体气体传感器可用于三甲胺的检测，但其灵敏度不够高且器件体积大，不能满足痕量气体探测的高灵敏度和高选择性需要。为解决这一关键问题，本项目创新性地利用卷曲纳米技术在电极上集成构筑贵金属/半导体金属氧化物异质纳米膜卷曲单根管Lab-in-tube微型气体传感器，实现对ppb量级三甲胺的高效检测，建立实验室条件下“电极-材料-器件-测试”的一体化技术路线。基于Lab-in-tube模型，系统研究纳米膜卷曲管结构参数与气敏性能之间的构效关系，揭示贵金属和半导体金属氧化物之间的界面协同作用及其对气敏性能的促进机制。本项目的研究结果将为其它挥发性有机物（VOCs）生物标志分子的高效检测提供新策略，也为发展其他微型传感器提供借鉴。

To develop highly novel and effective micro gas sensors for trimethylamine with high sensitivity is very meaningful for noninvasive exhaled breath diagnosis of chronic kidney disease. Many gas sensors with low sensitivity and large volume are reported for trimethylamine detection, however, they still cannot merit the requirement of miniaturization of devices with high sensitivity and high selectivity. This project is aimed at using the strain-engineered rolled-up nanotechnology to in-situ fabricate Lab-in-tube micro gas sensor based on a single rolled-up tube of noble metal/semiconductor metal oxide nanomembrane for trimethylamine detection with trace concentration on the ppb-level. An integrated technique route of “electrode-material-device-test” will be developed. Based on the Lab-in-tube model, the effect of structure parameters of the single rolled-up nanomembrane tubes on the sensing performances will be investigated. The interaction between noble metal and semiconductor metal oxide at the surface, and its promotion mechanism for gas-sensing performances will be revealed. The research results of this project will provide new strategies for efficient detection of other volatile organic compounds (VOCs) biomarkers, and will also conduce to the development of other micro gas sensors.