18F-PET示踪剂在PET/CT领域有着非常广泛的应用，特别是在肿瘤显像领域。以往的方法在制备18F-PET探针时往往需要多步合成、剧烈的反应条件，从而不可避免的造成副产物的生成、低放射性化学收率。从而严重的阻碍了18F-PET探针在PET/CT领域的应用，特别是基于肿瘤分子受体的PET/CT成像。本项目拟通过研究芳香氟磺酸酯（ArOSO2F）的18F-19F同位素交换反应来建立一种高效、便捷的制备18F-PET探针分子的原创性方法。在此基础上开展：1）靶向PARP-1的18F小分子PET探针的设计合成和成像研究；2）设计和合成一个基于点击化学的18F芳香氟磺酸酯工具箱，为肽类分子和抗体的18F标记的提供一种全新的方法。最终为该方法在其他疾病相关靶点的18F小分子、肽类或抗体PET探针中的应用提供实验基础。

Fluorine-18 ([18F]) probes are very popular in PET/CT area due to its favorable physical and chemical properties, especially in the tumor imaging area. However, traditionally the synthesis of 18F probes generally need very hash reaction conditions and multistep steps synthesis, which, thus led to undesirable byproducts and are usually isolated in low radiochemical yields, and has greatly hindered the development of 18F-PET probes in the PET/CT area, especially tumor targeting 18F-PET probes. This project aims to develop a novel, straight forward and efficient method for the synthesis of 18F-PET probes by the isotopic exchange reaction of aromatic fluorine sulfonates (ArOSO2F). To further demonstrate the utility of the methodology we plan to design and synthesis of a series of PARP-1 targeting 18F-PET probes and evaluate their in vivo imaging properties. We also plan to design and synthesis of a click chemistry tool box of 18F-fluorine sulfonate for peptide and antibody labelling and imaging.