基于自旋轨道电荷转移增强的系间窜跃调控机制(SOCT-ISC)的新型光敏试剂的构建及肿瘤光动力治疗研究
结题报告
批准号:
22004081
项目类别:
青年科学基金项目
资助金额:
24.0 万元
负责人:
苗俊峰
依托单位:
学科分类:
化学与生物传感
结题年份:
2023
批准年份:
2020
项目状态:
已结题
项目参与者:
苗俊峰
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中文摘要
光动力治疗(PDT)是利用光敏剂和光活化治疗癌症的新方法,具有时空分辨率高,副作用小,无耐药性等优点。当前,在PDT研究领域,绝大多数光敏剂的设计利用了重原子效应,然而重原子的引入不仅增加了光敏剂暗毒性风险,而且缩短了其三线态的寿命,从而影响了单线态氧量子效率。本项目围绕自旋轨道电荷转移促进的系间窜跃机制(SOCT-ISC),以Bodipy染料为基础,拟开发a-PeT型和d-PeT型两类无重原子的可见及近红外PDT光敏剂及其癌细胞靶向衍生物,并分别在模拟生理条件和细胞水平系统评价它们的结构和性能关系,三线态寿命、单线态氧量子产率、光毒性及暗毒性,进而应用到活体肿瘤的光动力治疗。本项目的学术贡献在于拓展了a-PeT型光敏剂并创新性提出了光稳定性更强的d-PeT型光敏剂,从而扩大了无重原子光敏剂的设计范围。目前,申请人已合成了本项目关键及代表性的光敏剂,并通过初步的实验证实了设计策略的可行性。
英文摘要
Photodynamic therapy (PDT) is a new method to treat cancer on the basis of photosensitizers and photo-activation, which has the advantages of high spatial and temporal resolution, small side effects, and no multi-drug resistance to cancer. To date, in the research field of PDT, most photosensitizers are designed using the heavy atom effect. However, heavy atoms not only increase the risk of dark toxicity, but also shorten the lifetime of triplet states that is detrimental to quantum efficiency of singlet oxygen. In this project, we design two types of heavy atom-free photosensitizers, i.e., a-PeT and d-PeT photosensitizers, as well as their cancer cell-targeted near-infrared derivatives based on spin–orbit charge-transfer intersystem crossing process (SOCT-ISC). The structure-performance relationship, triplet lifetime, singlet oxygen quantum yield, phototoxicity and dark toxicity, and PDT efficiency in mice tumor models of these photosensitizers would be systematically evaluated at the simulated physiological conditions and cell levels, respectively. The academic contribution of this project is to expand the design scope of heavy atom-free photosensitizers by designing new a-PeT type photosensitizers and innovatively proposing more photostable d-PeT type photosensitizers. At present, we have synthesized the key and representative photosensitizers of this project and confirmed the feasibility of our design strategy through preliminary experiments, which ensures the smooth development of the project.
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DOI:--
发表时间:2021
期刊:山西大学学报(自然科学版)
影响因子:--
作者:苗俊峰;翁嘉劲;霍莹莹;郭炜
通讯作者:郭炜
DOI:--
发表时间:2021
期刊:山西大学学报(自然科学版)
影响因子:--
作者:苗俊峰;霍莹莹;罗海艳;郭炜
通讯作者:郭炜
国内基金
海外基金