重度以上骨髓型急性放射病治疗，造血重建后患者仍死于继发多器官功能衰竭（MOF），目前尚无很好防治方法。炎症、感染和循环障碍是多器官功能衰竭发生的重要病因。辐射致组织细胞死亡和损伤释放的actin可致循环障碍、炎症和细胞毒等与MOF发生相关的病理效应。gelsolin具有清除actin疏通微循环，抗感染及限制炎症传播等多种功能，但能否在防治MOF中发挥作用尚缺乏系统研究。本课题在前期gelsolin辐射防护作用研究的基础上，进一步在细胞和整体动物水平明确循环gelsolina和actin消长与辐射损伤的关系；比较gelsolin表达量不同细胞和动物的辐射敏感性；观察补充外源性gelsolin对受照动物微循环、炎症和感染方面的影响，确定主要影响环节和途径，研究其在减轻辐射继发病理损伤中的主要作用机理。结果对于深入了解放射损伤病理发展规律，寻找防治辐射继发多器官功能衰竭的新方法有理论和实践意义。

The patients with severe bone marrow form of acute radiation sickness still died of multiple organ failure after successive treatment of hematopoietic reconstruction. No methods control for its occurrence righ now. Inflammation,infection and circulatory obstruction are important factor-induced MOF. Ionizing radiation induced release of the actin protein by cell death and damage can lead to secondary pathological effects like circulatory disorders,cytotoxity and inflammation which are associated with multiple organ failure. Recently gelsolin was found that could promote blood circulation by removing stasis caused by circulation actin and could also function as multi functions including antioxidant,antiinfectious and limiting inflammation spread.But less researches were done about functions and behaviours plaied by gelsolin in prevention and control of radiation induced secondary pathylogical damage.Based on early discoveries of anti-oxidation damage of radiation and promoting damaged animal survival in this project the relationship between radiation induced injuries and fluctuation value of gelsolin and actin in irradiated cell and animal will be systematically observed; radiation sensitivity in the levels of cells and mice with different gelsolin expression will be well compared; by observing of the indexes including tissue and cell damage,microcirculatory disorders,infection and inflammation associated with changes of gelsolin quantity during different pathological stages of acute radiation sickness animal model when damage animal was supplied with gelsolin after exposure; the linkage and pathyway of gelsolin action will be determined; the role and mechanism of gelsolin in anti secondary radiation pathological damage will be deeply studied. Results will be great significance to understand impact factors of radiation injury and look for new control methods for radiation induced MOF.