超声辐射激励型光学相干弹性成像技术应用基础研究

针对临床上眼组织生物力学性质在体检测方法的应用需求，开展眼前节在体弹性性质的量化评估及实时监测方法研究，从理论层面分析，提出一种基于超声激励生物组织的检测力学特性光学相干弹性成像新方法，拟采用以声辐射力激发眼前节组织形成剪切波，利用光学相干弹性成像技术对眼前节组织硬度进行成像和量化分析，重点开展图像成像和生物力学性能测定研究，阐明剪切波传播速度与生物力学的映射关系，突破眼前节组织诊断及治疗过程中矫正屈光度不正的瓶颈技术，形成眼前节组织有效耦合和动态波束合成算法，发展高空间分辨率的无创性技术，为测量眼前节组织的生物力学特性奠定技术基础，研制一套可用于临床的检测眼前节组织生物力学特性的声光系统。

Aiming at the application requirements of the bio-mechanical properties of the ocular tissue in vivo, the quantitative evaluation and real-time monitoring methods of the anterior segment of the anterior segment were carried out. From the theoretical analysis, an optical property of the detection of mechanical properties based on ultrasonic excitation was proposed. A new method of coherent elastography is to use the acoustic radiation force to stimulate the formation of shear waves in the anterior segment of the eye. The optical coherence elastic imaging technique is used to image and quantify the hardness of the anterior segment of the eye, focusing on image imaging and biomechanical performance measurement. The mapping relationship between shear wave propagation velocity and biomechanics breaks through the bottleneck technique of correcting diopter error in the diagnosis and treatment of anterior segment of the eye, forming an effective coupling and dynamic beamforming algorithm for the anterior segment of the eye, and developing a non-invasive technique with high spatial resolution. To lay a technical foundation for measuring the biomechanical properties of the anterior segment of the eye, a set of acousto-optic systems for clinical biomechanical properties of the anterior segment of the eye were developed.