利用分子生物学技术鉴别未知个体的民族属性或地域来源对刑事侦查工作具有重要的指向性作用。近年来，一些重要研究发现EPAS1和EGLN1基因SNP遗传位点多态性差异普遍存在于藏汉人群之间并成为保证藏族人群成功适应高原环境的因素之一。鉴于此，本项目拟通过分析甘肃天祝藏族自治县、甘肃甘南藏族自治州内各300名无关藏族个体和世居藏区300名无关汉族个体及兰州地区300名无关汉族个体EPAS1和EGLN1基因的26个SNP位点多态性，利用回归分析法验证藏汉人群SNP多态性差异鉴别刑事案件中已知人员个体民族或地域属性鉴定的正确率和可靠性，从而在国内外首次提出并循证了利用SNP遗传位点多态性差异对藏汉民族未知人员个体的民族属性或地域来源进行鉴定的可行性和科学性，为人类分子遗传标记应用于刑事侦查工作提供了实践参考。

National or geographical origin identitying at molecule level of unknown individual gives an important direction for the forensic workers. Recently, some important studies found the universality of SNPs polymorphism differences in EPAS1 and EGLN1 between Tibetan and Chinese Han, which ensures Tibetan's successfully adaptation on high altitude.In this issue, we study the difference of 26 SNP loci in EPAS1 and EGLN1 among 300 Tibetan individuals and 300 Han individuals in Tianzhu Tibet Autonomous County, 300 Tibetan individuals and 300 Han individuals in Gannan Tibet Autonomous County, and 300 Han individuals in Lanzhou City of Gansu Province. By the regression analysis method, it was studied the feasibility of identifying the ethnic attribution or geographical origination among background-known populations in forensic research area.Furthermore, this research present and investigate the feasibility and science of identifying national attributes or geographical source of the Chinese and Tibetan populations by SNPs polymorphism differences in EPAS1 and EGLN1 for the first time, which provides a practical reference for human molecular genetic markers used in criminal investigations.