代谢综合征严重危害到人类健康，而几乎所有的抗精神病药物都不同程度的引起代谢综合征的不良反应，遗传因素在其中起着非常重要的作用。但目前对抗精神病药物引起代谢综合征的遗传机制尚不明确。转录因子7类似物2（TCF7L2）和锌转运子（SLC30A8）基因是发现与代谢综合征相关性最强的基因，抗精神病药物可以直接影响这两个基因的蛋白表达，提示TCF7L2 和SLC30A8基因在抗精神病药物引起的代谢综合征的遗传机制中起着非常重要的作用。本项目将用前瞻性对照方法研究抗精神病药物奥氮平对大鼠胰岛β细胞的TCF7L2 与SLC30A8基因蛋白表达的影响及精神分裂症病人的TCF7L2与SLC30A8基因多态性与抗精神病药物引起代谢综合征的相关性，明确TCF7L2与SLC30A8基因及其蛋白表达在抗精神病药物所致代谢综合征中的遗传作用机制，为预防和治疗抗精神病药物引起的代谢综合征提供理论依据。

Metabolic syndrome is seriously harm to our health. Almost all of antipsychotics can induce metabolic syndrome. Genetic factors play a key role in the development of metabolic syndrome, but the mechanism is still unclear.TCF7L2 and SLC30A8 are strongestly correlated with metabolic syndrome. Moreover, antipsychotics have an effect on the expression of TCF7L2 and SLC30A8 genes. It indicates the variations of TCF7L2 and SLC30A8 play an important part in the development of antipsychotic-induced mtabolic syndrome. In this study, we will determine the effect of olanzapine on the expression of TCF7L2 and SLC30A8, and the relationship of the polymorphism of TCF7L2 and SLC30A8 with antipsychotic-induced metabolic syndrom in schizophrenia patients. This application, if successsful, we will provide theoretic supports for the prevention and treatment of antipsychotic-induced metabolic syndrome.