OSAHS相关性高血压是一种最常见的抵抗性高血压。研究证实其发病机制可能与代谢性炎症及醛固酮分泌增多等有关。补体C1q肿瘤坏死因子相关蛋白1（C1qTNF-related protein-1，CTRP1）通过调节代谢性炎症及醛固酮的生成而可能成为OSAHS相关性高血压血压升高的重要调节物质。TNF-α、IL-1β及NGFIB、NURRA是调节CTRP1生成及使其发挥作用机制的重要物质。课题应用测序技术筛查CTRP1及TNF-α、IL-1β、NGFIB、NURRA基因变异位点，TaqMan-PCR技术在大样本人群中进行基因型鉴定，在小样本人群脂肪细胞检测CTRP1及其相关物质RNA及蛋白含量，通过病例-对照研究拟从DNA、RNA、蛋白质等不同水平探讨CTRP1及其相关物质与OSAHS相关性高血压的关系，为OSAHS相关性高血压今后的机制研究提供研究基础。

OSAHS-related hypertension is one of the most common resistant hypertension, to which the metabolic inflammation and excessive aldosterone secretion are suggested as the contributing factors. Complement C1q tumor necrosis factor related protein 1 (C1qTNF-related protein-1, CTRP1 ) is supposed to play a role in the pathogenesis of OSAHS-related hypertension due to its role in regulating the metabolic inflammation and aldosterone production. Besides, TNF alpha, beta- IL-1βand NGFIB, NURRA are key factors to the production and function of CTRP1. This study is designed to discuss the associations between CTRP1 and its related factors and OSAHS-related hypertension via comparing DNA, RNA and protein levels by case-control studies, including the detection of variants in CTRP1, TNF alpha, beta- IL-1βand NGFIB, NURRA genes, identification of genotypes by Taqman-PCR in general population, tests of the RNA and protein levels of CTRP1 and its related factors. On a whole, we intend to provide evidence for the further explanation to the mechanism of OSAHS-related hypertension.