lncRNA与肝癌发生发展密切相关。近期研究表明，位于lncRNA上的SNP可改变lncRNA与miRNA的结合能力,进而影响下游基因的表达，最终导致肿瘤的发生发展。这些SNP是否可通过该途径影响肝癌预后，尚不清楚。前期，我们从TCGA申请获得了300余例肝癌患者的全基因组SNP基因分型数据。通过插补分析和功能注释，找到了多个落在lncRNA上且影响lncRNA-miRNA互作的SNP位点。结合临床预后信息进行的生存分析以及结合多组学分子分型信息进行的关联分析表明，这些位点与肝癌预后显著相关。本研究拟在此基础上：1）通过表达数量性状分析和蛋白数量性状分析寻找这些SNP作用的目标基因；2）在1000例肝癌病人中，对上述位点进行验证；3）通过一系列功能实验，对这些位点的具体作用机制进行研究。本项目通过鉴定新的肝癌预后位点，并阐明其分子机制，可为肝癌精准治疗及药物开发提供新思路。

lncRNA were associated with prognosis of liver cancer. A recent study showed that, SNPs in lncRNA can regulate downstream gene expression by influencing the interaction of lncRNA with miRNA. Whether these SNPs can affect the prognosis of liver cancer through a similar way, is unknown. Recently, we applied and received whole genome genotyping data of more than 300 liver cancer patients from TCGA. By imputation analysis and functional annotation, we find large amounts of SNPs located in lncRNA and influence its binding with miRNA. By further survival analysis and subtype association analysis, we further found some SNPs of them were significantly associated with the prognosis of liver cancer. Based on the above analysis, We want to do the following research: 1) find target genes of these SNPs by eQTL analysis and pQTL analysis; 2) confirm the association of these SNPs with the prognosis of liver cancer in 1000 Chinese HCC patients; 3) find the functional mechanism of these SNPs by a series of experiment. By identifying new liver cancer prognosis-associated SNPs and classify the mechanism of them, our study will provide new ideas for precision treatment and drug development of liver cancer.