功能MOFs材料的设计、合成及其在天然药物分离中的应用

金属-有机框架(MOFs)材料具有孔隙率高、比表面积大、孔径可调以及拓扑结构多样和选择吸附等特性，在气体存储、催化、及载体材料领域具有较广泛的应用，近年来将其用于小分子手性化合物分离方面也有少量报道。然而将功能性MOFs材料用于天然药物分子的分离纯化方面还未见报道。在天然药物分子提取分离过程中，如何高效、快速地分离纯化天然药物分子一直是困扰该研究的关键科学难题。因此，我们结合在新型功能MOFs材料研究方面的深厚积累以及在天然药物分子分离纯化方面的最新进展，率先提出开展功能性MOFs材料应用于天然药物分子中的分离纯化研究思路。设计合成3-5类结构新颖、性能(酸性、碱性、中性)不同的功能性MOFs材料，并将其用于分离巴戟天和野生狔猴桃根提取物中的甾体、生物碱、萜类和多糖分子。拓展MOFs材料应用领域，同时从中药中发现新结构的单体分子。

Metal-organic frameworks (MOFs) have been intensively evaluated as a promising kind of gas storage materials, owing to their exceptionally high surface areas, remarkable physicochemical stability and adjustable pore structures. The MOFs have been used in the separation of small chiral molecules. However, the use of functional MOFs for the separation and purification of natural plant molecules has not been reported. During separation of natural plant molecules, we can’t purify some compounds (the enantiomers, isomers and chiral molecules) completely using the conventional separation methods. It is so essential to find the new methods for efficient separation and purification of natural plant molecules. Therefore, based on the wonderful achievements about the synthesis and characterization of MOFs and the progress of isolation of natural products obtained by our group, we take the lead to isolate the natural compounds using the functional MOFs materials as the chromatographic packing. In this project, we will design and synthesis three to five different kinds of functional MOF materials, and use these MOFs as the chromatographic packing to isolate the steroids, alkaloids, terpenoids and polysaccharides from the extraction of Morinda Officinalis and the roots of Actinidia Chinensis Planch, which will expand the application scopes of MOFs and at the same time, discover the new compounds from these plant medicines.