低临界溶解温度（LCST）型水溶性高分子作为智能型材料得到了广泛应用，特别是生命科学领域。为满足生物体内实际应用，通常要求其LCST值接近人体正常温度，并且温度的调节幅度尽可能小。对于传统的温敏性高分子，往往需要通过改变单体计量比，共聚反应得到不同LCST的高分子，这种方法繁杂且不可逆。将动态的主客体识别体系引入高分子侧链，从而实现简便、准确的LCST调控是为一种新途径。本项目拟将修饰有乙二醇单甲醚的柱芳烃作为侧基引入高分子链，使高分子不但具备良好的温敏性和生物相容性，且能通过主客体作用更好地调控LCST行为。我们期望通过柱芳烃与高分子的有机结合实现新型温敏性高分子的构建，并对其LCST机理、细胞毒性和控制释放性质作进一步的研究与阐释。预期本项目的研究工作能为水溶性温敏高分子的研究提供新的思路。

Water-soluble polymers exhibiting lower critical solution temperature(LCST) are ptentially useful for smart bioactive materials. However, it is tedious and irreversible to adjust the LCST values close to body temperature which is necessary for real applications. By introducing host-guest recognition motif into thermoresponsive polymers as side chains provide an opportunity to adjust LCST expediently and precisely. In the project, we plan to ingraft oligo(ethylene glycol) modified pillararene onto polymers as side chains. In this way, we can get themoresponsive poloymers with excellent thermosensitivity and biocompatibility. Moreover, we are able to tune the LCST in a better way through host-guest interacions. We aim to construct novel thermoresponsive polymers via reasonable combination of pillararene and polymers. Furthermore, the LCST behavior mechanism, cell toxicity and control-release properties of thermoreponsive polymers will be explored and elaborated. This work will open up a new way to study water-soluble thermoresponsive polymers.