以金为主的贵金属纳米结构，由于其独特的与其尺寸和形貌高度相关的plasmonic（金属等离激元）光学特性，近年来在生物传感和纳米医学领域引起了人们广泛兴趣和极大关注。本项目选取纳米尺度精细设计制备的plasmonic 杂化纳米结构作为新型化学和生物传感平台, 结合课题组多年来在plasmonic 杂化纳米结构设计/制备及应用方面积累的优势和特色, 围绕有关的生物/纳米界面问题开展分析化学基础研究。项目以核-壳型或其它特殊结构plasmonic 杂化纳米粒子单元为主, 选取若干感兴趣的化学和生化分析对象，通过适当表面化学修饰并结合特异酶反应体系构筑灵敏的plasmonic传感探针，采用光学检测方法并借助表面增强拉曼、表面增强荧光等谱学方法，在分子和细胞水平上开展新型化学和生物传感的分析化学基础研究。

Gold-based nanostructures with nanoengineered structures, tunable optical properties and integrated functionality have attracted much attention recently since such nanostructures have the potential to revolutionize biosensing and nanomedicine applications, due to their unique optical and photothermal propeties caused by localized surface plasmon resonance. In this project, we focus on design and controlled synthesis of novel hybrid plasmonic nanostructure，especially Au-based core-shell-type nanostructures, and using them as a novel platform for ultrasensitive sensing and biosensing applications. Besides chemical modification, specific enzymatic systems will also be used to design novel nanoplasmonic probes, and optical methods and surface-enhanced spectroscopy will be employed for (bio)sensing studies on molecular and cell levels.