SEBM3D打印制备的Ti6Al4V合金骨科植入件存在大幅降低弹性模量、避免毒性元素、导向性构建多种生物学功能、表面功能化改性等尚需满足的性能和功能需求。因此，本项目瞄准含生物活性元素Si等的新一代生物医学植入件Ti合金，多要素综合分析构建高强度、低弹性模量β型Ti合金的成分设计理论；采用多目标优化函数，确立性能与功能驱动的本体致密、表面多级梯度孔径搭配的复合结构材料（简称“复合材料”）的模型优化设计方法；选择自主研制的小束斑SEBM装备，成形复合材料并揭示其缺陷抑制策略及组织性能调控机制；利用基于高级氧化的水热/溶剂热法，实现复合材料表面微/纳功能性分子筛涂层改性，并揭示其对组织再生微环境的构建及多种生物学功能的导向性作用机制。本项目在选题、学术思路与制备技术等方面极具创新性，将从合金设计理论、制备工艺机理、生物学机理等三方面突破新一代生物医学植入件复合材料临床应用的瓶颈。

Ti6Al4V orthopedic implants produced by 3D printing of SEBM (selective electron beam melting) have some performance and function requirements needed to be met, i.e., reducing largely elastic modulus, avoiding toxic elements, building orientedly multiple biological functions, modifying functionally alloys surface, etc. On this account, this project aims at the bioactive element Si-containing new-generation beta-type Ti alloys for biomedical implants, establishes composition design theory of beta-type Ti alloys with high strength and low elastic modulus by comprehensive analysis of multiple factors, founds optimized modeling design method derived by performance and function for multi-structure built materials (called multi-structure materials herein) combining nearly-full-density matrix with multimodal-gradient-pores surface microporous structure using multi-objective optimization function, forms multi-structure materials via self-developed small-spot SEBM equipment and further reveals their defect suppression strategies and microstructure-performance regulation mechanisms, prepares functional surface-modification layers of zeolites through hydrothermal/solvothermal method based on advanced oxidation, and finally clarifies the effects of multi-structure materials and their functional surface-modifications of zeolites on construction of tissue regeneration microenvironment and related orientedly built mechanism for multiple biological functions. In summary, this project is very innovative in topics, academic ideas and preparation technology, and can conquer the bottleneck of clinical application of the new-generation multi-structure materials for biomedical implants from three aspects of alloys design theory, preparation mechanism and biological mechanism.