基于叔胺型两性离子前体聚合物的促健康愈合可降解植入材料研究

植入材料的组织相容性在植入器件和药物控释等领域决定着治疗手段的成败。然而，已有的植入材料仍然面临人体排异的挑战，缺乏健康的愈合过程，植入体最终被致密胶原囊膜隔离或降解后遗留患者不可接受的疤痕。拟研究项目将遵循伤口适量炎症促进健康愈合的机制，利用两性离子聚合物所具有的抗蛋白质非特异性吸附能力和叔胺基团易于氧化的特性，设计了可降解叔胺型两性离子前体聚合物植入材料，利用其在体内具有长效抗蛋白质吸附能力和抗细胞粘附能力，抑制多核异体巨细胞形成；通过调控降解产物诱发适量炎症，并结合叔酸型两性离子对氧化和酸化压力的缓解能力，诱导巨噬细胞向M2表型极化，增加促修复生长因子分泌，加速健康愈合。以期最终实现无致密胶原囊膜和疤痕/结节，新生毛细血管正常分布的健康愈合。实现这一目标将可以解决植入材料组织相容性难题，拓宽其在植入器件和药物控释等领域的应用，对植入材料的设计与制备具有重要学术价值和实际意义。

Implanted biomaterials plays a decisive role for successful implantation of devices and drug carriers. However, the body’s immune system recognizes such implants as foreign body, and encapsulates them with a dense collagen capsule or forms scar through a, unhealthy healing process. To overcome it, we proposed a novel type of poly carboxybetaine (CB) ester analogue based material with long-term resistance to nonspecific protein adsorption and cell adhesion for healthy wound healing. The excellent resistance will reduce the acute inflammation caused by initial nonspecific protein adsorption and activation of the platelets, and the chronic inflammation through suppressing foreign body giant cell formation. Moreover, the controllable degraded debris could cause the mild inflammation to recruit more inflammation-related cell to generate the enough cytokines to accelerate wound healing. The tertiary amine on the poly (CB) could reduce the stress caused by too high concentration of reactive oxygen species (ROS) and acidity, which could protect the cells in surrounding tissue and control the intensity of inflammation, as well as induce the polarization of macrophage to M2 phenotype. As a result, the implants could be healthily healed without a dense collagen capsule or scar, and with health vascularization. It is believed that the successful achieve of this goal will promote the rational design of the degradable biomaterials and widen the application of implanted devices and drug carriers.