生物驻极态对调节细胞行为和正常功能以及疾病发生的机制有重要作用。项目基于血管病变和神经退行性病变中生物分子及极化状态的变化，提出调控生物大分子结构和形态，构建微米介孔和三维多孔结构的仿生生物驻极体，通过位移极化、驰豫极化或自发极化，获得在不同尺度三维结构上稳定可控的空间电荷极化和驻极状态； 探讨生物驻极体的结构参数、电荷分布和储存密度及生理条件下的驰豫规律，并研究体内外生物驻极体对病变神经细胞、血管内皮细胞等形态、细胞活性、髓鞘化、细胞亚结构、特异蛋白表达的影响，以及对间充质干细胞的免疫调控，获得和验证不同仿生驻极体的电介特性和驻极态性能对细胞功能作用的定性定量实验数据和规律。该研究将揭示了多尺度三维结构生物驻极体的极化和去极化状态及对特异细胞的作用规律，为促进退行性神经细胞和血管病变的再生和功能重建提供新的实验方法和理论依据，对于生物驻极体的理论研究和临床医学应用具有重要意义。

Bioelectret plays an important role in regulating cell behavior and normal function as well as the mechanism of disease.Project based on biological molecules in vascular lesions and neural degenerative diseases and the change of polarization state, put forward to control biological macromolecular structure and form, build the micron mesoporous and three-dimensional porous structure of bionic biological electret, through the displacement polarization and relaxed polarization or spontaneous polarization, get on the different scale three-dimensional structure stable and controllable polarization and space charge in state;Discusses biological structure parameter of electret, charge distribution and storage density and under the condition of the physical relaxation law of biological electret in vivo and in vitro and study the pathological changes of nerve cells and vascular endothelial cell morphology, cell activity, myelin sheath, cell structure, the influence of the specific protein expression, as well as to the mesenchymal stem cells of the immune regulation, obtain and verify the dielectric properties of different bionic electret and performance in a state of qualitative and quantitative experimental data regularity of cell functions.The study will reveal the multi-scale three-dimensional structures of biological electret state of polarization and depolarization and the role of the law on the specific cells, to promote the degenerative nerve cells and vascular lesions of the regeneration and functional reconstruction provides a new experimental method and theoretical basis, for biological electret theory research and clinical application is of great significance.