茶组植物起源于我国，包括重要园艺作物茶树及其野生近缘物种共12种。该组种质资源的利用多限于茶树一种，其它近缘物种资源利用极其有限。营养健康价值导向的资源评价是促进茶组植物种质资源利用的重要途径。茶树的降脂活性已被广泛证实，但茶组物种间降脂活性的种效关系尚不明确，产生降脂活性的物质基础有待深入研究。本项目拟利用脂代谢异常动物模型评价茶组物种的降脂活性，依据多指标表征结果归纳出茶组物种降脂活性的种效关系。同时，利用代谢组学手段解析茶组物种的全代谢物组成。继而，通过正交偏最小二乘回归分析预测化学组分与降脂活性的相关性，通过购买、分离、合成等方式获得高相关性成分，再利用上述动物模型评价所得化合物单体的降脂活性，并进一步研究高活性化合物对茶组物种降脂活性的增效作用，阐明茶组物种降脂活性的物质基础。项目的实施将对营养健康价值导向的茶组物种资源评价、保护、发掘和利用提供理论依据，为茶树育种提供新的思路。

Sect. Thea originated from China, including the important horticultural crop Camellia sinensis and its wild relatives totally count for 12 species. The plant resource of Sect. Thea was rarely utilized except Camellia sinensis. The lipid lowering activity of Camellia sinensis was widely approved, while the species-activity network within Sect. Thea and the material basis are still not clear. This project is to employ the lipid metabolism disorder animal model to evaluate lipid lowering activity of Sect. Thea species, conduct the species-activity network according to multiple biomarkers, use UPLC-Orbitrap-MS analyze the chemical profiling, introduce OPLS-regression analysis to predict the correlation between chemicals and bioactivity. Next, acquire the highly correlated compounds through purchasing, isolation or synthesis, evaluate the lipid lowering activity of the candidate compounds, further explore the synergistic effect of the bioactive compounds to Sect. Thea species, finally elucidate the material basis of the lipid lowering activity of Sect. Thea. This project will provide theoretical evidence for nutritional and health value guided evaluation, protection, exploration and utilization of Sect. Thea species, and give new thoughts for the plant breeding of Camellia sinensis.