项目拟在前期“新疆维吾尔族骨性关节炎遗传基因表达谱及其多样性研究”的基础上首先通过临床横断面调查研究的方法确立膝关节置换围手术期患者中医证候变化的特点与分布规律，继而采用双向凝胶电泳技术(2-DE)、质谱技术(MS)和RT-PCR等技术对新疆维、汉民族膝骨性关节炎患者软骨、滑膜、关节液中的蛋白质进行筛查与鉴定。探讨与分析维、汉民族膝关节置换围手术期中医证候变化特点与分布特征，以及膝骨性关节炎发病的特异性蛋白与差异性蛋白，并从基因调控、蛋白表达的角度上阐释该病发病的可能机制，通过本项目有望在发现膝骨性关节炎发病新的相关蛋白-分子标记物，找出维、汉两个民族膝骨性关节炎患者之间的差异性所在，最终为新疆骨性关节炎患者的诊疗提供理论依据。

Project in early "xinjiang uygur osteoarthritis genetic gene expression patterns and their diversity research" on the basis of the first established by the method of clinical cross-sectional study knee replacement perioperative TCM syndrome in patients with changes in the characteristics and distribution of, and then USES the two-dimensional gel electrophoresis (2 DE), mass spectrometry (MS) and rt-pcr technique in xinjiang, the han nationality patients with knee osteoarthritis cartilage, synovial membrane, screening and identification of the protein in joint fluid. Discussion and analysis, the han nationality knee replacement perioperative TCM syndrome change characteristics and the distribution characteristics, and the specificity of the knee osteoarthritis pathogenesis proteins with differences in protein, and from the perspective of gene regulation, protein expression on explain the possible mechanism of the disease, the disease through the project is expected to find new knee osteoarthritis pathogenesis related protein - molecular markers, identify two dimension, han ethnic differences between patients with knee osteoarthritis, eventually provide theoretical basis for diagnosis and treatment of osteoarthritis patients in xinjiang.