本项目基于申请人团队在脑血管病诊疗工作中的基础，拟以颅内动脉粥样硬化一级预防及二级预防的患者为研究对象，使用三维高分辨磁共振管壁成像技术进行全脑斑块成像，采用影像组学的分析方法对斑块进行定量分析，通过规律随访，根据有无粥样硬化进展及缺血性脑血管病事件再发，识别高危斑块，提取有意义的影像组学特征，进一步建立高危斑块诊断模式，为颅内动脉粥样硬化性斑块危险分层提供新的思路和方法，同时，分析高危斑块特征与缺血性卒中相关基因多态性的关系；基于斑块影像组学、临床资料及基因，研究新疆地区粥样硬化性卒中发病机制特点，比较维吾尔族及汉族人群发病机制的差异，以期建立一站式、精准化、个体化的诊断、治疗决策体系，最终提高一级预防及二级预防效果，减少缺血性卒中发生率及再发率。

Based on the previous works in cerebrovascular disease, in the present study, our group aimed to perform the Radiomics analysis of atherosclerotic plaques imaged by three-dimensional high-resolution vessel wall magnetic resonance imaging in primary and secondary prevention patients with intracranial atherosclerosis. Radiomics traits of each plaque were extracted. According to the progression of intracranial atherosclerosis and occurrence of ischemic event during the follow-up, we firstly identify the culprit plaques which was responsible for the qualifying event and secondly select the Radiomics traits, then a diagnosis model was build to identify the high-risk plaques after Logistic regression. Meanwhile, the association between the selected traits and specific genetic polymorphism was evaluated. According to the Radiomics features, clinical materials and genetic information, we aimed to investigate the atherosclerotic stroke mechanism in Xinjiang region and the differences of stroke mechanism between Uighur ethnic group and Han ethnic group. The study will help to establish an one-stand examination, precise diagnosis system in the intracranial atherosclerosis, and promote the efficacy of primary and secondary prevention in this disease.