生物发酵液是一类重要的生物质基衍生物，其中ABE发酵液是燃料和化学品的主要来源之一。生物发酵液浓度低、分离能耗高，因此，理想的利用途径是直接催化转化，简化分离过程。然而，目前对于发酵液的可控催化转化，同时实现高转化率和产物高选择性仍面临巨大挑战。申请人前期实现了多相催化ABE发酵液的直接转化，选择性制备4-庚酮，然而，催化剂活性与抗积碳能力欠佳。针对上述问题，本项目拟研究高效、稳定的多相催化体系，聚焦氧化铈缺陷位点与双金属脱氢位点微环境的调控；原位探测反应活性物种与积碳物种的生成与演变，明晰反应与失活机理，提出抗积炭的策略；结合技术、经济可行性分析，最终实现高效、选择性制备4-庚酮。该项目的顺利开展将架起生物发酵与化学催化的桥梁，为生物质资源高值化利用打开新的出口，既具有科学研究意义，又具有潜在的工业应用价值。目前，初步的研究结果证明了该项目的可行性。

Fermentation broth is an important derivative of biomass and ABE fermentation broth (acetone-butanol-ethanol) has been widely used as fuel and chemicals. Due to its low concentration, the complexity/cost of the purification process limits its widespread practical applications. Thus, an ideal way is to convert the ABE fermentation directly. However, the efficiency and selectivity of the transformation process remains a major techno-economic challenge. In the previous work, we realized the conversion of aqueous ABE fermentation broth to 4-heptanone selectively. Although the selectivity is high, the catalytic activity of the catalyst is low with weak carbon deposition resistance. Here, we propose to develop an active catalyst with long-term stability, majorly focusing on the tune of defect sites and bimetallic sites for dehydrogenation of alcohols. Furthermore, the formation and evolution of the intermediate and coke species will be tracked, investigating the reaction and deactivation mechanism. A combination of techno-economic analysis will realize the efficient and selective transformation of ABE fermentation broth to 4-heptanone. It bridges the gap between biological fermentation and chemical catalysis, expanding the high value applications of biomass. At the moment, the preliminary results confirm the feasibility of this project.