利用平板印刷技术和UV光固化技术优异的成型性，基于巯基-Michael加成反应，以具有良好生物相容性、可降解性和形状记忆效应的PGS作为基材，通过必要的化学改性使PGS携带可参与光固化反应的基团，构建巯基/甲基丙烯酸酯/异氰酸酯正交固化体系，通过分步成型的方式，精确控制交联网络的结构和密度，从而达到对最终产物力学性能和形状记忆效应的调控。系统研究巯基/甲基丙烯酸酯/异氰酸酯体系的光固化动力学，共聚物组成、固化工艺参数与交联结构、密度的内在关系，共聚物交联结构和PGS结晶结构与形状记忆效应之间的影响关系，以及最终产物的生物相容性和可降解性，从而揭示出“分子组成—制备条件—交联结构—材料性能”之间的内在规律。相信通过本项目的深入研究，有助于扩大巯基官能团“点击化学”反应的应用范围，为设计、开发新型具有复杂结构且兼具形状记忆效应的软组织工程材料提供新思路和必要的理论基础。

With the aid of excellent manufacturability of lithography and UV curing technology, the copolymer, which has good biocompatible, biodegradable and shape memory effect, will be photopolymerized by thiol-methacrylate-isocyanate orthogonal reaction system based on thiol-Michael addition reaction, through chemical modification of PGS as base material. Precise controllable crosslinking network and density will be obtained by two-stage UV curing, and the mechanical properties and shape memory effect of copolymer will be also effectively controlled by this way. The project will focused on the curing kinetics of thiol-methacrylate-isocyanate reaction, the intrinsic relationships between copolymer composition, curing process parameters, crosslinking structure and density, also research crosslinking and PGS crystallization on the influence of the shape memory effect, biocompatibility and biodegradability. Finally, the inherent law between the “molecular composition, preparation conditions, crosslinking, materials properties” will be revealed. It is believed that the scientific research of this project will help expand the application of thiol group “click chemistry” reaction; at the same time, the study of the project will certainly provide new ideas and the necessary theoretical basis for design and development complex structure of soft tissue engineering materials with shape memory effect.