新疆特色药穆拉合松弛膏结合西医康复护理改善废用性关节挛缩的临床及疗效机制研究

废用综合征（DS）是机体长期丧失活动能力或持续不能活动而导致的继发性障碍，其中废用性关节挛缩在康复训练中涉及复杂的生理机理，可能会造成患者病情反复发作进而难以控制，而关于康复护理方式干预废用性关节挛缩相关报道较少。申请者在前期研究表明，中西医结合综合康复护理方案对关节挛缩患者关节挛缩的改善有较好的疗效，可有效提高患者的运动功能、日常生活活动能力（ADL）及生活质量（QOL）；穆拉合松弛膏康复护理兔关节挛缩模型前后药效、血液动力学和关节活动度（ROM）均有统计学意义。本项目拟在已有研究工作基础上，临床试验分析穆拉合松弛膏结合西医康复护理废用性关节挛缩的疗效和预后价值；通过蛋白和代谢组学研究，结合生物信息学探索中西医结合康复护理改善废用性关节挛缩的关键蛋白和代谢通路。同时在动物模型中进一步深入探讨其发生作用的调控分子机制。最终阐明新疆特色药结合西医康复护理废用性关节挛缩的临床疗效及作用机制。

Disuse syndrome (DS) is a secondary disorder caused by the body's long-term incapacitation or continuous inactivity. Among them, disuse joint contracture involves complex physiological mechanisms in rehabilitation training, which may cause patients to relapse repeatedly and become difficult Control, and there are few reports about the intervention of rehabilitation nursing methods for disused joint contracture. The applicant's previous research showed that the integrated rehabilitation nursing intervention program of traditional Chinese and Western medicine has a good effect on the improvement of joint contracture in patients with joint contracture, and can effectively improve the patient's motor function, daily life activities（ADL） and quality of life（QOL）; Mu Lahe relaxation cream Before and after nursing rabbit joint contracture model, the drug efficacy, hemodynamics and joint mobility (ROM) were statistically significant. Based on the existing research work, this project intends to analyze the clinical effect and prognostic value of Mu Lahe Relaxing Ointment combined with Western medicine rehabilitation nursing disused joint contracture; through protein and metabolomics research, combined with bioinformatics to explore the integration of Chinese and Western medicine Rehabilitation nursing improves key proteins and metabolic pathways of disused joint contracture. At the same time, further explore the molecular mechanism of its regulation in animal models. Finally, the clinical efficacy and mechanism of Xinjiang specialty medicine combined with basic rehabilitation nursing for disused joint contracture are clarified.