脑出血后血肿清除是减轻脑出血所致原发及继发损伤的关键。现有外科手段尽管可有效清除血肿，但存在手术相关损伤及风险，如何通过无创手段促进血肿清除应为脑出血治疗研究的新方向。我们前期研究发现，脑出血后内源性Axl在小胶质细胞上表达增加，并通过膜受体剪切和胞内段磷酸化影响下游免疫调控信号，而外源性rGas6可强化Axl的活化及免疫调控信号传导，并改善神经功能结局。然而具体调控方式尚未完全阐明。我们进一步发现Axl的功能强化促进脑出血后血肿吸收；细胞实验也初步提示，高表达Axl的小胶质细胞存在更强的胞葬能力。由此我们推测，小胶质细胞在Axl调控轴介导下的胞葬作用为脑出血后血肿清除的关键步骤。本研究拟从动物、细胞、分子等层次阐明小胶质细胞在Axl信号介导下的作用方式，确定脑出血早期血肿清除过程中胞葬作用的关键起始信号，并探寻可行的干预方案。据此，该研究可望为脑出血早期血肿吸收提供新靶点及依据。

Hematoma clearance is crucial in reducing brain injury related with intracerebral hemorrhage (ICH). Surgeries inevitably result in injury and risks. Our previous study found that, endogenous Axl was increased and expressed on microglia cells after ICH. Its cleavage of ectodomain and phosphorylation of endodomain regulated downstream immune-regulatory signals, which can be further enhanced by rGas6. However, the modulatory pattern is not well illustrated. We then found that Axl may improve the hematoma clearance after ICH, and microglia with high-expressed Axl revealed greater ability of efferocytosis. Thus, we inferred that, the efferocytosis introduced by microglia with high-expressed Axl may play pivotal role in the hematoma clearance. In this research, we aim to clarify specific mechanism conducted by Axl on microglia cells, to confirm the key initial signal of efferocytosis, and to explore promising treatment. Hopefully, this research will provide potential target for ICH therapies.