有机小分子和金属联合不对称催化

不对称催化是合成手性有机分子最高效的方法。有机小分子和金属联合催化剂可同时或连续活化多个化学键并使其有序重组，因此能够发展单一催化剂难以实现的反应。手性有机小分子和金属联合催化正成为均相不对称催化的一个新兴研究领域。本项目以发展新型催化剂体系和高效不对称反应为目标开展相关研究，主要内容有：（1）发展新型手性亲核Lewis碱/金属联合催化剂体系及其催化的不对称碳氢官能团化反应、多组分和串联反应；（2）手性布朗斯特酸和钯配合物联合催化的炔烃和烯炔的不对称转化；（3）手性布朗斯特酸和金配合物接力催化的基于金卡宾中间体的不对称串联反应；（4）有机小分子/金属联合催化的机理研究。通过本项目的实施，使有机小分子/金属联合不对称催化在国际上保持领先甚至引领的地位。

Asymmetric catalysis has been accepted as the most efficient pathway to access chiral molecules. The asymmetric organocatalysis combined with metal catalysis integrates the catalytic activity of metal and organocatalysts to allow the simultaneous or sequential occurrence of multiply bond-breaking and forming events in stereoselective manner, and has thereby been considered an emerging field. The proposal will be focused on the development of new combined catalyst systems consisting of chiral Lewis bases and transition metals, together with the creation of unprecedented asymmetric reactions. The research projects include (1) the development of new chiral Lewis base/metal combined catalyst systems and their applications in catalyzing asymmetric C-H functionalization reactions, multicomponent and cascade transformations, (2) Asymmetric transformations of alkynes and enynes under the combined catalysis of chiral Brønsted acid and palladium complexes, (3) chiral Brønsted acid/gold relay catalytic cascade reactions proceeding via gold carbene species, and (4) the reaction mechanism of the organo/metal combined catalysis. The realization of the proposed project will result in new findings that exert significant impact on the asymmetric catalysis and will bring leading position in the related fields.