银屑病是一种顽固的皮肤疾病，目前认为是由T细胞介导的慢性炎症性皮肤疾病，其影响全世界2-3％的个体。有研究估计，2013年全球治疗银屑病及相关的费用就超过1,120亿美元。在过去的50年的大量研究表明主要组织相容性复合体（MHC）分子（也称为人白细胞抗原（HLA））是许多复杂疾病的主要致病基因。多项研究确认，HLA-C*06:02是银屑病的最强易感基因。HLA-C*06:02存在于60％以上的患者中，单独这一基因使患银屑病的风险增加了9到23倍。进一步的研究表明，HLA-C*06:02分子的97和15位氨基酸是其致病机制中最关键的氨基酸。本研究将HLA-C*06:02将用作模型分子，系统地研究其97和156变异分子的结构和功能特性，并根据这些特性筛选小分子抑制剂。研究将为了解银屑病的发病机理提供重要的帮助。同时也将为临床治疗银屑病提供新的思路。

Psoriasis is a stubborn skin problem that is considered to be a T-cell-mediated chronic inflammatory skin disease and affects 2-3% of individuals worldwide. Studies have estimated the annual cost of psoriasis in the world to exceed $112 billion in 2013. In the past 50 years, variants in the major histocompatibility complex (MHC) locus, also known as the human leukocyte antigen (HLA), have been reported as major risk factors for complex diseases. Many Studies have confirmed that HLA-C*06:02 is a strongest susceptibility gene in psoriasis. HLA-C*06:02 is present in more than 60% of patients, increases the risk for psoriasis 9- to 23-fold. Further studies showed that the 97 and 156 amino acids of HLA-C*06: 02 molecule where the most critical amino acids in its pathogenesis. In this study, HLA-C*06:02 will be served as a model molecule to systematically study the structural and functional characteristics of its 97 and 156 variant molecules, and to design and screen small molecular inhibitors based on these characteristics. The study will provide important help to understand the pathogenesis of psoriasis. It will also provide a new promise way for the clinical psoriasis treatment