经历单电子氧化过程的新反应研究及其在环系合成中的应用

本次申请拟通过单电子转移方式氧化反应底物，形成活泼的自由基正离子中间体，实现反应底物的活化；进而通过碳氢键断裂转化为碳正离子或自由基中间体发生后续反应，实现底物分子的碳氢键官能团化。以探索“绿色催化体系”及“新型反应底物”为主要切入点，以发展“氧化脱氢环化反应”为重点，侧重于研究符合绿色化学和可持续发展化学要求的温和条件下的新反应及其机理，并将探索其在复杂环系合成中的应用。

This project proposes to activate substrates to generate reactive radical cation intermediates through single electron transfer, which then convert to carbocation or radical intermediates for further reactions by C-H bond broken. This project focuses on the exploration of 'green catalytic systems', 'new substrates' and 'oxidative dehydrogenative cyclizations' in the one electron oxidation promoted C-H functionalization and will place extra emphasis on those new efficient reactions which meet the requirement of green chemistry and sustainable chemistry. The reaction mechanism and the application in the synthesis of complex rings will be also explored.