由细菌造成的疾病和感染严重威胁着人类的健康。介孔二氧化硅材料由于其优异的性质，广泛应用在抗菌药物载体的研究。传统的介孔二氧化硅载体具有光滑的表面形貌，缺乏与菌体之间的作用力，降低了药物传递效率，严重限制了其抗菌性能。本项目拟采用限域自组装策略，构建兼具内部规则介孔结构和表面分形结构的药物载体。其内部介孔结构提供载药空间，同时载体表面的分形结构提高载体与细菌的结合力，从而提高载体药物传递效率，提高抗菌效能。本项目拟考察二氧化硅限域自组装过程中，反应物浓度、温度、催化剂等动力学因素对分形结构形貌的影响，研究介孔材料表面分型结构的调控规律；探讨限域自组装策略在不同性质介孔材料表面的普适性，并拓展抗菌载体的种类和功能；研究具有不同复合结构形貌载体的抗菌性能，阐明和揭示介孔-分形复合结构对载体抗菌性能的协同调控机制；为开发新型高效的抗菌药物载体和新型抗菌技术提供新材料和新理论。

The diseases and chronic infections caused by bacteria are a main threat to human health. Mesoporous silica has been being widely used in antibacterial drug carrier research due to the excellent properties. The smooth surface of traditional mesoporous silica carrier causes the lack of interaction between the carrier and bacteria, which has seriously limited the drug delivery efficiency and antibacterial effect. This project will try to fabricate the drug carrier with both periodic mesoporous pores and fractal structure on the surface, by using the confined self assembly stratagy. The mesopores could provide drug loading space, while the fractal structure could enhance the interaction to the bacteria, which could improve the antibacterial effect. This project will try to study the the influence of kinetic factors on the morphology of fractal structure during the confined self assembly process; summarize the principles in the controllable fabrication of fractal structure on the mesoporous silica surface; study the application of confined self assembly stratagy on other mesoporous surfaces with different properties; expand the categories and functions of antibacterial carrier; reveal the synergistic regulation mechanism of mesoporous-fractal composite structure on the antibacterial effect. The project will try to provide new materials and theories for the developing of new antibacterial carrier and technology.