中药制药工业对膜技术具有重大需求，而严重膜污染问题制约了膜技术在中药制药工业中的推广应用。中药水提液中的共性高分子（淀粉、蛋白质、果胶、鞣质等）是其产生膜污染的主要污染物，而共性高分子与膜的微界面作用是中药水提液产生膜污染的作用基础。基于此，本项目拟开展以下工作，研究中药水提液膜法分离的微界面作用：（1）采用扫描电镜、原子力显微镜、红外光谱等检测技术，采集共性高分子、不同微滤及超滤膜的理化性质，运用胶体与界面化学研究领域的XDLVO理论，定量解析二者的微界面作用；（2）采用分子模拟、膜污染试验等方法，应用支持向量机等数据挖掘算法，发现与验证微界面作用与膜污染的相关性，建立中药水提液膜污染的量化评价体系；（3）通过调节溶液环境、膜表面性质等方式，调控微界面作用，优化膜分离过程。通过以上研究，揭示中药水提液膜法分离的微界面作用，阐明中药水提液膜污染微观作用机制，形成优化膜分离过程的调控技术。

Chinese medicine industry has a great realistic demand for the membrane technology. However, the serious membrane fouling problem has restricted the popularization and application of the membrane technology in pharmaceutical industry of traditional Chinese medicine. The common polymers (starch, protein, pectin, tannins, etc.) in traditional Chinese medicine water extract were the major membrane pollutants and the micro-interface between common polymers and membranes was the basis for membrane fouling produced by traditional Chinese medicine water extract. Based on these, this project intends to study the micro-interfacial interaction of the membrane separation process of traditional Chinese medicine water extract from the microscopic scale, and developed the following research work:(1) The physicochemical property parameters of the common polymers and different microfiltration and ultrafiltration membranes were collected using detection techniques including scanning electron microscope, atomic force microscope, infrared spectroscopy and so on. The XDLVO theory in the field of colloids and interface chemistry was used to quantitatively analyze the micro-interfacial interaction.(2) Research methods including molecular simulations, membrane fouling tests and data mining algorithms such as expenditure vector machines, were used to discover and verify the correlation between micro-interfacial interaction and membrane fouling, and to establish a quantitative evaluation system for the membrane fouling of traditional Chinese medicine water extract.(3) By adjusting the environment of the solution, the nature of the membrane surface, etc., the micro-interfacial interaction was regulated and the membrane separation process was optimized. Based the above studies, the micro-interfacial interaction of membrane separation of traditional Chinese medicine water extract and the microscopic mechanism of membrane fouling of traditional Chinese medicine water extract was revealed, and the regulation technology for optimized membrane separation process was formed.