角质形成细胞自噬在银屑病发病机制中的作用研究

自噬是细胞利用溶酶体降解自身受损的细胞器和大分子物质的过程，其既是细胞内的再循环系统，也是机体重要的防御和保护机制，对于维持细胞内环境的稳定以及抵御病原体入侵至关重要。银屑病是由于机体固有免疫和获得性免疫发生紊乱，在二者的病理协同作用下，产生大量的细胞因子、趋化因子及生长因子，进而导致皮损部位炎症细胞浸润、炎症网络逐级放大，以角质形成细胞异常增生分化为主要特征的自身免疫性皮肤病。我们认为，角质形成细胞的自噬行为可能与维护表皮细胞动力学稳定相关，而且作为一种重要的机体皮肤免疫细胞，其自噬行为也可能会在自身免疫性皮肤病银屑病的发病机制中也具有重要的影响作用，对于该科学问题，国内外尚无相关报道。我们希望对其深入探讨，为进一步理解皮肤自身免疫疾病的发生发展提供新思路。

Autophagy is the process that cells use lysosomal degradation of their own damaged organelles and macromolecules.As both intracellular recycling system and the body's important defense,it's important for protection mechanisms of the maintenance of cell homeostasis and defense against pathogens invasionis.Psoriasis is an autoimmune skin disease that is characterized by abnomal proliferation and differentiation of keratinocyte.Due to innate and acquired immune disorders in pathological synergy process, the body produce large amounts of cytokines, chemokines and growth factors,leading to inflammatory cell infiltration and inflammation amplification in the lesional skin.We suppose that autophagy of keratinocyte may play an important role in the cell kinetics and immunopathogenesis of psoriasis.