以尘肺病为代表的职业性呼吸系统疾病约占我国职业病病例总数的90%。可以说，职业性呼吸系统疾病的诊治是我国职业病防治工作的重中之重。但遗憾的是，我国目前在这一领域仍面临重重困局。其根本原因在于不同行业的生产性粉尘在几何特征及理化性质等方面存在巨大差异，职业性呼吸系统疾病因而具有显著的行业特征。鉴于此，申请人创新性地提出了从机理角度研究颗粒物几何特征及理化性质对其在人体呼吸道内运动和沉积规律的影响，并且开展了大量的前期工作，获得了一系列重要的研究成果。本项目正是对前期工作的进一步深入和细化，拟通过与医疗一线单位密切合作，借助高精度医学影像及临床检测手段深入分析疾病特征；研究颗粒物几何及物性参数对动力学特征的影响；建立相应的理论和数值计算模型，获取不同性状颗粒物在人体呼吸道内的沉积模式图谱；为预测、评估和诊断职业性呼吸系统疾病提供准确的前端数据，同时也为今后提高我国职业卫生水平奠定坚实的基础。

Occupational respiratory diseases, mainly represented by pneumoconiosis, accounts for 90% of occupational diseases in China. In another word, diagnosis and treatment of occupational respiratory diseases is the key priority in China to promote the occupational health. Unfortunately, there are challenges yet to overcome. The main reason is that high variations in both geometry and physicochemical property are found for productive dust that is created from different industries. It has been a challenge to classify and diagnose occupational respiratory diseases using a generic mathematical or empirical model. To bridge this research gap, the applicant innovatively proposed to model particles’ transport and deposition in the human respiratory system by simulating movements based on their geometrical features and physicochemical properties. Previously the applicant has conducted a series of high-quality researches and achieved outstanding outcomes. Based on previous results, this project will achieve further development of the particle transport model by following ways: i). we will collaborate with a hospital, which hosts high-precision medical imaging equipment and clinical interventions, to gain insights of characteristics of different occupational respiratory diseases, ii). we will investigate particle-airflow dynamics influenced by particle’s geometrical features and physicochemical parameters, iii). by combining results achieved from last two steps, we will build theoretical and numerical models, to predict particle deposition patterns in the respiratory system according to their properties, iv). we will use the developed model to provide required information for doctors to predict, evaluate and diagnose occupational respiratory diseases and offer proper treatment. In addition, this will lay a solid foundation to raise the quality of occupational health in China.