DNA甲基化结合蛋白对COPD气道炎症的影响和机制

我们最近的研究发现与慢性阻塞性肺疾病（COPD）特异相关的DNA加合物BPDE等，并发现DNA加合物通过影响气道表遗传学改变而在COPD的发病中发挥重要作用。本项目拟在此基础上进一步研究DNA甲基化CpG结合蛋白（MBD）对DNA加合物诱导的气道表遗传学中的影响，以及在COPD气道慢性炎症中的作用。先研究MBD蛋白对DNA加合物诱导的气道表遗传学包括DNA甲基化和组蛋白修饰的影响和机制，然后研究MBD蛋白对气道炎症的作用及机制。这是我们近年来科研工作的逻辑延伸，通过完整的阐明MBD对外界环境作用于人体的切入点-DNA加合物的影响，以及在COPD发病中的作用，为进一步研究外界环境如何作用于人体导致COPD的形成提供科学的依据。

Our recent studies have found that DNA adduct BPDE and others were specific related to the chronic obstructive pulmonary disease (COPD), and found that DNA adducts played an important role in the pathogenesis of COPD through airway epigenetic changes. Based on these, The project intends to further study the effect of DNA methylation CpG-binding protein (MBD) on airway epigenetic changes, and the airway chronic inflammation in COPD. Firstly, we will study the effect of of MBD on DNA epigenetic changes including DNA methylation and histone modification induced by DNA adducts and mechanisms, and then study the influence of MBD on airway inflammation and mechanisms. This is the logic extension of scientific research work in recent years, it leads to a complete clarification of the contribution of MBD in the entry point-DNA adducts of the external environment that acts on the human body, and the pathogenesis involved in COPD, and provide a scientific basis for the further study of how the external environment in the human body.