RDGN对气道慢性炎症和气道重构的影响以及在COPD发病中的研究

慢性阻塞性肺疾病（COPD）在全球范围内的发病率和死亡率逐年升高，气道慢性炎症和气道重构是COPD发生的主要机制。视网膜决定基因网络（RDGN）是一种与肺发育和肺部疾病相关的信号网络。我们在前期研究中发现：RDGN中的Dach1，Six1和Eya1在COPD患者和正常人群中的表达存在差异，并导致气道中炎症因子的表达的差异。本课题拟在此基础上，进一步研究RDGN对气道慢性炎症和气道重构的影响和机制。首先研究RDGN对炎症因子表达的影响和机制；然后研究RDGN对气道细胞增殖的影响和机制；最后研究RDGN表遗传学改变在RDGN致炎症表达和细胞增殖中的作用。旨在深入探讨RDGN如何影响气道炎症因子的产生和细胞增殖凋亡，并最终通过气道慢性炎症和气道重构的形成而导致COPD的发生，从而为COPD的预防和治疗提供新的理论依据。

Chronic obstructive pulmonary disease (COPD) is characterized by persistent airway inflammation and airway remolding. Its morbidity and mortality are rapidly increasing worldwide. Retinal decided gene networks (RDGN) is a signaling network that is related to pulmonary development and lung disease. In recent studies, we found that the level of dachshund (Dach1), sine oculis homebox 1(Six1) and eyes absent (Eya1) were different in the lung tissues between with COPD and normal control, and it resulted in the difference of inflammatory cytokines in the airway of these groups . On the basis of these researches, we planed to further study the influence of RDGN in the mechanism of chronic inflammation and airway remolding. Firstly, we will study on the effect of RDGN on the expression of inflammatory cytokines and mechanism, and then study the influence of RDGN on airway cell proliferation and mechanism. Lastly, we will study the epigenetic changes of RDGN in airway inflammatory and cell proliferation. It aims to further explore how RDGN to affect the expression of inflammatory cytokines and cell proliferation, and eventually leads to chronic airway inflammation and airway remodeling in the occurrence of COPD, which would provide a new theoretical basis for the prevention and treatment of COPD.